Results 181 to 190 of about 3,107,063 (298)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

2025 AHA/ACC blood pressure guideline and HEARTS 2.0: implications for the future evolution of integrated cardiovascular-kidney-metabolic care in the Americas. [PDF]

Rev Panam Salud Publica
DiPette DJ, Battle SJ, Rosende A, Brettler J, Jaffe MG, Whelton PK, Ordunez P.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Geological society of America. Bulletin.

Voortzetting van: Bulletin of the Geological Society of America [ISSN 1050 ...
Geological society of America
core  

From Accra to America: Putting development first in global health. [PDF]

PLOS Glob Public Health
Ratevosian J, Menson WNA.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

High-resolution South American wind resource data downscaled with generative machine learning conditioned on near-surface observations. [PDF]

Data Brief
Benton BN, Igwe V, Buster G, Rough D, Maclaurin G.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Bibliographical society of America. Papers.

Voortgezet als: Papers of the Bibliographical society of AmericaVoortzetting van: Bibliographical society of America.
Bibliographical society of America
core  

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated <i>Plasmodium vivax</i> malaria in Latin America. [PDF]

Lancet Reg Health Am
Nguyen K, de Pina-Costa A, Rajasekhar M, Chamma-Siqueira NN, Daher A, Ferreira MU, Gomes MDSM, Gonzalez-Ceron L, Green JA, Koh GCKW, Ladeia-Andrade S, Llanos-Cuentas A, Monteiro WM, Negreiros SC, Macedo de Oliveira A, Pereira DB, Viana GMR, Vieira JLF, Zuluaga-Idarraga LM, Alatawi HHM, Guerin PJ, Simpson JA, Lacerda MV, Price RN, Siqueira AM, Commons RJ.   +25 more
europepmc   +1 more source