Results 101 to 110 of about 15,375,091 (267)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Independent Advisory Group on Sustainability: Final Report to the Inter-American Development Bank [PDF]
, 2011 The Independent Advisory Group on Sustainability (IAG) is pleased to submit this final report to the Board of Executive Directors and Management of the Inter-American Development Bank (IDB).
Inter-American Development Bank
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Inter-American Development Bank Annual Report 2007
, 2008 This Annual Report contains a brief summary of the economic situation of Latin America and the Caribbean and a review of the Bank\u27s operations in 2007.
Inter-American Development Bank
core +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Pets as Traveling Companions in Selected 20th-century Narratives of American Road Trips
Acta Universitatis Wratislaviensis. Anglica WratislaviensiaTravel authors usually emphasize that in order to truly encounter the Other and discover oneself a traveller needs to be alone, free from family obligations and home responsibilities.
Małgorzata Rutkowska
doaj +1 more source
Inter-American Development Bank Cultural Center Annual Report 2006
, 2007 This report summarizes the activities of the IDB Cultural Center in 2006. During 2006, the Center promoted the IDB\u27s role as a regional multilateral organization concerned with the development of Latin America and the Caribbean.
Inter-American Development Bank
core +1 more source
The Bank in the Central American Isthmus and the Dominican Republic: 2015 Activities Report [PDF]
, 2016 The world outlook in 2015, marked by financial market volatility, a downturn in the world economy and the El Niño phenomenon, has not prevented the countries of the Central American isthmus and the Dominican Republic (hereinafter, the region) from ...
Inter-American Development Bank
core +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Inter-American Development Bank Cultural Center Annual Report 2003
, 2004 During 2003, the IDB Cultural Center (CCN) celebrated its 11th Anniversary and expanded outreach and visibility of its activities in Europe and the Region, thanks to its four programs and new partnerships.
Inter-American Development Bank
core +1 more source