Results 61 to 70 of about 31,258 (246)

Black bear density in Glacier National Park, Montana

Wildlife Society Bulletin, 2014
We report the first abundance and density estimates for American black bears (Ursus americanus) in Glacier National Park (NP), Montana, USA. We used data from 2 independent and concurrent noninvasive genetic sampling methods—hair traps and bear rubs ...
Jeff B. Stetz, Katherine C. Kendall, Amy C. Macleod   +2 more
doaj   +1 more source

Identification of carnivore kill sites is improved by verified accelerometer data

Animal Biotelemetry, 2020
Background Quantifying kill rates is central to understanding predation ecology. However, estimating kill rates and prey composition in carnivore diets is challenging due to their low densities and cryptic behaviors limiting direct observations ...
Tyler R. Petroelje, Jerrold L. Belant, Dean E. Beyer, Nathan J. Svoboda   +3 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Late season frosts and changing snowpack may exacerbate human–bear conflicts

Ecosphere
The North American black bear (Ursus americanus) is an opportunistic omnivore that depends on seasonal availability of fruits, nuts, grasses, and forbs for survival.
Kevin T. Shoemaker, Heather E. Reich, Perry J. Williams, Megan J. Osterhout, Joshua P. Vasquez, Jon P. Beckmann, Carl W. Lackey, Kelley M. Stewart   +7 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Unintentional toxicosis from methylxanthines in chocolate‐based baits consumed by American black bears

Wildlife Society Bulletin, 2016
The use of baits often increases success for many wildlife management activities, including wildlife capture for research, harvest by hunters and trappers during regulated activities, and lethal and nonlethal control for damage management.
Jeff Beringer, Andrew Timmins, Tim L. Hiller   +2 more
doaj   +1 more source

Systemic Racism, Police Brutality of Black People, and the Use of Violence in Quelling Peaceful Protests in America

Age of Human Rights Journal, 2020
The Trump Administration and its mantra to ‘Make America Great Again’ has been calibrated with racism and severe oppression against Black people in America who still bear the deep marks of slavery.
Williams C. Iheme
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Evaluation of dexmedetomidine, tiletamine, and zolazepam for the immobilization of black bears

Wildlife Society Bulletin, 2015
Telazol® (TZ, tiletamine hydrochloride [HCl] and zolazepam HCl) has been used to immobilize black bears for research and management activities since the 1980s. Although considered an effective and safe drug, TZ has some disadvantages, including prolonged
Jessica A. Coltrane, Sean Farley, David Saalfeld, David Battle, Tony Carnahan, Justin Teisberg   +5 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source