Results 81 to 90 of about 7,997 (209)

The prolonged epidemic of anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: 'bringing down the neighbourhood'.

, 2003
In order to investigate the distribution and causes of the spread of anthroponotic cutaneous leishmaniasis (ACL) in Kabul, Afghanistan, a cross-sectional study was conducted during 1997-98 amongst 75,787 residents in the 13 central districts of the city.
Rowland, Mark, Davies, Clive, Khan, Bismulla, Reyburn, Hugh, Mohsen, Mohammmed   +4 more
core   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

The ecology and control of cutaneous Leishmaniasis vectors in the sub-Andean mountainous zone of Huila department, Colombia [PDF]

This thesis describes a series of studies designed to improve our understanding of the transmission cycle of cutaneous leishmaniasis (CL) in the coffee-growing sub-Andean region of Huila department and to explore the use of ...
Pardo Puentes, Raul Hernando
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

American tegumentary leishmaniasis mimicking myiasis and granulomatous vasculitis: A case report

Asian Pacific Journal of Tropical Medicine
Rationale: American tegumentary leishmaniasis comprises cutaneous and mucocutaneous manifestations caused by parasitic infections by various Leishmania species.
Victoria J Arrieta, Gastón Morea, Leticia M Tennerini, María V. Sanchez, Esteban S Lozano, Diego E Cargnelutti   +5 more
doaj   +1 more source

Translational Pharmacokinetic‐Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI‐6148 for the Treatment of Cutaneous Leishmaniasis

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Cutaneous leishmaniasis is a neglected tropical disease with only one oral treatment option. DNDI‐6148 is an orally bioavailable compound with potent antiparasitic activity in preclinical studies. Establishing skin target‐site pharmacokinetic/pharmacodynamic (PK/PD) relationships is essential to enable its clinical development.
Rasmus Hansen Henninger, Wietse M. Schouten, Byron Arana, Jean‐Yves Gillon, Charles E. Mowbray, Jadel Müller Kratz, Katrien Van Bocxlaer, Thomas P. C. Dorlo   +7 more
wiley   +1 more source

Occurrence and sociodemographic behavior of American cutaneous leishmaniasis in Vicência, Pernambuco, in the period from 2007 to 2014

Semina: Ciências Biológicas e da Saúde, 2017
Leishmaniasis is a neglected disease that is among the top five endemic infectious and parasitic diseases of major relevance. The aim of this study was to analyze the frequency, the demographic, and epidemiological profile of the patients with ...
Patrícia Pereira Vasconcelos, Natália Jerônimo de Araújo, Francisca Janaína Soares Rocha   +2 more
doaj   +1 more source

Two Leishmania species circulating in the Kaleybar focus of infantile visceral leishmaniasis, northwest Iran: implications for deltamethrin dog collar intervention

, 2008
Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of a few isolates from patients and domestic dogs, this parasite was considered to predominate in the Kaleybar ...
Ready, P. D. (Paul Donald), Parvizi, P, Mazloumi-Gavgani, A. S., Davies, CR, Ready, PD, Courtenay, Orin, P.D. Ready, P. Parvizi, A.S. Mazloumi-Gavgani, C.R. Davies, Parvizi, P., Courtenay, O, O. Courtenay, Mazloumi-Gavgani, AS, Davies, C. R.   +14 more
core   +1 more source

Leishmaniosis ¿When to Hospitalize?

Kasmera, 2009
Leishmaniasis is an endemic parasitic infectious disease of worldwide distribution. In Venezuela the main characteristics correspond to american tegumentary leishmaniasis (cutaneous l calized, cutaneous-mucous, cutaneous diffuse) and visceral ...
Pedro Navarro, Jorge Riera, Ana Carvajal, Silvya Silva, Luis Colmenares, Haydeé Ríos, Karla Romero, Virginia Coraspe, Marisela Silva, María Antonia De la Parte   +9 more
doaj