Results 101 to 110 of about 860,870 (372)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Dental students′ compliance with antibiotic prescribing guidelines for dental infections in children

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2016
Context: To investigate the antibiotic prescribing training received by dental students, clinical experience in treating child patients, awareness of antibiotic prescribing guidelines, preparedness in antibiotic prescribing, and compliance with ...
Yee Chen Wong, Mandakini Mohan, Allan Pau   +2 more
doaj   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Toward Optimal Health for All:: The American Dental Association Takes on Sugar and its Impact on Oral Health. [PDF]

Dela J Public Health, 2023
Shepley GR.
europepmc   +1 more source

Antenatal and Intrapartum Risk Factors for Use of Emergency and Restorative Medicaid Dental Services for Children [PDF]

, 2015
Purpose: To investigate the relationship between antenatal/intrapartum factors and Medicaid use. Methods: Three databases were used: (1) birth records; (2) Medicaid files; and (3) Medicaid dental claims.
Bush, Heather M., Li, Hsin-Fang, Nash, David A., Talbert, Jeffrey, Yepes, Juan F.   +4 more
core  

Analysis of Abstracts Presented at the Prosthodontic Research Section of IADR General Sessions 2004–2005: Demographics, Publication Rates, and Factors Contributing to Publication [PDF]

, 2011
Purpose: The purposes of this study were to describe the demographics of abstracts presented at the prosthodontics section of IADR General Sessions from 2004 to 2005, evaluate the publication rate of abstracts, and analyze the relationship between ...
Barao, Valentim A. R., Lee, Damian J., Prasad, Soni, Shyamsunder, Nodesh, Sukotjo, Cortino, Yuan, Judy Chia-Chun   +5 more
core   +2 more sources

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Bacteremia originating in the oral cavity. A review [PDF]

, 2008
In patients at risk because of heart disease, bacteremias induced by invasive dental treatments have been reported as a cause of bacterial endocarditis (BE) - a serious disorder that continues to involve a high mortality.
Carbonell Pastor, Enrique, Gavaldá Esteve, Carmen, Jiménez Soriano, Yolanda, Margaix Muñoz, María, Poveda Roda, Rafael, Sarrión Pérez, María Gracia   +5 more
core  

Dental amalgam fillings: An under-investigated source of mercury exposure [PDF]

, 2019
Dental amalgam fillings, which contain about 50% mercury, have been used since the early 19th century. However, their use has been controversial, particularly because they continually release small amounts of mercury.
Ahlqwist, Ahlqwist, Ahlqwist, Bailer, Bangsi, Barregard, Barregard, Barregard, Bates, Bellinger, Bellinger, Bellinger, Bjorkman, Bjørklund, Boyd, Bratel, Bratel, Casetta, Clarkson, Clarkson, Counter, Daniels, de Burbure, DeRouen, Dye, Eti, Factor-Litvak, Ganss, Goldwater, Gun, Herrstrom, Herrstrom, Herrstrom, Herrstrom, Hsu, Hujoel, Hyson, Kingman, Lund, Malt, McGrother, Melchart, Nylander, Rothwell, Sandborgh-Englund, Saxe, Saxe, Schuurs, Seidler, Siblerud, Siblerud, Siblerud, Soler, Sun, Woods, World Health Organization   +55 more
core   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source