Results 101 to 110 of about 5,205,295 (314)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

“Rebellion in the Ranks”: Desertion and the United States Colored Troops: An Interview with Jonathan Lande

open access: yes, 2017
Over the course of this year, we’ll be interviewing some of the speakers from the upcoming 2018 CWI conference about their talks. Today we are speaking with Jonathan Lande, a doctoral candidate in History at Brown University, where he was the 2016 Peter ...
Luskey, Ashley Whitehead
core  

Federal Holidays: Evolution and Current Practices [PDF]

open access: yes, 2014
[Excerpt] Since 1870, numerous proposals have been introduced in Congress to establish permanent federal holidays. Only 11, however, have thus far become law.
Straus, Jacob R
core   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Beyond the Annals of Murder: The Life and Works of Thomas M. McDade [PDF]

open access: yes, 2019
Thomas M. McDade is best known (if not well-known enough) for his seminal 1961 reference bibliography, The Annals of Murder: A Bibliography of Books and Pamphlets on American Murders from Colonial Times to 1900.
Behrens, Jennifer L.
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

[Review of] Gretchen M. Bataille and Kathleen M. Sands. American Indian Women, Telling Their Lives [PDF]

open access: yes, 1985
American Indians are not conquered. The heart of the American Indian woman is not on the ground. In taking over the control of the telling of her life, she preserves the reality and meaning of tribal history and culture.
Scott, Carol J.
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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