Results 31 to 40 of about 24,877,626 (266)

The petrosal and bony labyrinth of extinct horses (Perissodactyla, Equidae) and their implications for perissodactyl evolution [PDF]

PeerJ
Perissodactyla, or odd-toed ungulates, are represented today by 16 species of rhinoceroses, tapirs, and horses. Perissodactyls were much more diverse in the past, having a rich fossil record spanning from the earliest Eocene (~56 Ma) to recent, including
Owen Axel Goodchild, Sydney Nicole Rosen, Bastien Mennecart, Jin Meng, Jérémy Tissier   +4 more
doaj   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

From learners to contributors: how an AI-infused STEM program shaped youth identity and initiated them to an AI-future

Frontiers in Education
The expanding role of Artificial Intelligence (AI) across society has created new demands for K–12 education to support young people in developing foundational AI literacies.
Mark Weckel, Preeti Gupta, Katherine S. Moore, Rachel Chaffee, Irene Lee, Gabrielle Rabinowitz, Safinah Ali   +6 more
doaj   +1 more source

United States Bureau of Mines Bulletin 439 [PDF]

, 1941
From Purpose of Report: "This paper is based partly upon the authors' observations and partly upon studies of tunnel driving; these cover essentially all types of tunnels in various parts of the United States during the past 25 years.
Harrington, D., Ash, S. H. (Simon Harry), b. 1889   +1 more
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Symposium: Redefinitions of Citizenship and Revisions of Cosmopolitanism—Transnational Perspectives

Journal of Transnational American Studies, 2011
The following set of essays consists of revised versions of contributions read at, or prepared for, a roundtable discussion at the 2009 convention of the American Studies Association in Washington, DC.
Günter H. Lenz, Rob Kroes, Rüdiger Kunow, Alfred Hornung, William Boelhower   +4 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Practical Rubrics for Informal Science Education Studies: (1) a STEM Research Design Rubric for Assessing Study Design and a (2) STEM Impact Rubric for Measuring Evidence of Impact

Frontiers in Education, 2020
Informal learning institutions, such as museums, science centers, and community-based organizations, play a critical role in providing opportunities for students to engage in science, technology, engineering, and mathematics (STEM) activities during out ...
Bobby Habig, Bobby Habig
doaj   +1 more source

United States, northern border 1878

, 1878
Index map title: Index map, Joint Series. Shows the United States and Canadian border from the summit of the Rocky Mountains to the northwest angle of the Lake of the Woods. Relief shown by hachures and spot heights. Title from second sheet. First sheet
United States Northern Boundary Commission
core  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source