Results 61 to 70 of about 1,943,131 (350)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Democracy in Crisis, the Specter of Authoritarianism, and the Future of Higher Education [PDF]
, 2015 As the forces of neoliberalism gain ascendency in the United States, democratic public spheres must confront a growing crisis—one that impacts subjectivity as much as the material conditions in which most people must now struggle to survive. Politics has
Giroux, Henry A
core
Las editoriales independientes en el punto de mira literario: balance y perspectivas teóricas
Caravelle, 2019 This paper aims to define the material and cultural practices of the independent Latin American publishers of the 21st century, a phenomenon that has recently captured the Academy’s attention, from the categories of literary theory and criticism, in ...
Ana Gallego Cuiñas
doaj +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
RUDN Journal of Political Science, 2016 Article considers the interrelation of political and religious interests in the USA during the current presidential campaign. In particular, the author considers such aspects as mentality and culture of the American society.
O A Frolova
doaj
Nineteenth-century America through the Eyes of John Gennadius
Historical Review, 2015 The aim of this article is to unfold and analyze the view of America held by John Gennadius [Ioannis Gennadios], one of the most important diplomats of nineteenthcentury Greece.
Marianna D. Christopoulos
doaj +1 more source
Historic Caddo Archaeological Sites in Cherokee County, Texas [PDF]
, 2016 The historic archaeology of the Caddo Indian peoples in East Texas has been the subject of considerable interest by Caddo archaeologists for a number of years. Much of that interest has been focused on the investigation of the effects of European contact
Perttula, Timothy K. +2 more
core +1 more source
Dad Rudd, M.P. and the making of a national audience
, 2015 This article contextualizes Ken G. Hall's 1940 film Dad Rudd, M.P. with the history of Dad Rudd, a fictional character who pervaded Australian popular culture throughout the first half of the twentieth century.
Lamond, Julieanne
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Historia i Polityka, 2019 The aim of the paper is to identify and describe the policy positioningof the Democratic Party and the Republican Party as concerns access to firearms duringthe 2016 presidential election in the USA.
Aleksy Borówka
doaj +1 more source