Results 91 to 100 of about 44,777 (258)
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
Secondary Signing Location in American Sign Language
Annual Meeting of the Berkeley Linguistics Society, 1992 Proceedings of the Eighteenth Annual Meeting of the Berkeley Linguistics Society: General Session and Parasession on The Place of Morphology in a Grammar (1992), pp.
openaire +2 more sources
Advanced Science, EarlyView.Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai +10 more
wiley +1 more source
Advanced Science, EarlyView.CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen +19 more
wiley +1 more source
Deaf and Hearing American Sign Language-English Bilinguals: Typical Bilingual Language Development. [PDF]
J Deaf Stud Deaf Educ, 2023 Goodwin C, Lillo-Martin D.
europepmc +1 more source
Advanced Science, EarlyView.Metal‐anode batteries using Li, Na, Mg, and Ca offer exceptionally high energy density, but dendrites, unstable interphases, cracking, and pore formation hinder durability and safety. This review shows how careful electrolyte and interphase design can stabilize these reactive metals.
Jian Pan +3 more
wiley +1 more source
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
Unlocking the potential of Zimbabwe's sign language
Namibian Journal of Linguistics, Literature and Communication StudiesThis article explores the manner in which the underdevelopment of Zimbabwean Sign Language (ZSL) has prevented ZSL from developing into an equally developed language in Zimbabwe.
Tawanda Matende +3 more
doaj +1 more source
Toward the Effective Animation of American Sign Language. [PDF]
, 2001 American Sign Language (ASL) is the primary language used by the North American Deaf Community. We present our method for producing natural animations of fingerspelling, a functionally important subset of ASL. User testing demonstrates that our animations are readily identified by members of the deaf community.
Sedgwick, Eric +15 more
openaire +2 more sources
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source