Results 121 to 130 of about 538,903 (313)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

In the shadow of the ICC: Colombia and international criminal justice [PDF]

The report of the expert conference examining the nature and dynamics of the role of the International Criminal Court in the ongoing investigation and prosecution of atrocious crimes committed in Colombia.
Cantor, David, Engstrom, Par, Human Rights Consortium, Institute for the Study of the Americas, Institute of Commonwealth Studies, O'Brien, Éadaoin   +5 more
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Real-World Data on Metastatic Lung Cancer: Cost Analyses in Brazil From a Private Insurance Company's Perspective

JCO Global Oncology
PURPOSENon–small cell lung cancer (NSCLC) is often diagnosed at late stages, leading to escalated treatment expenses. This study aimed to elucidate the costs of lung cancer treatment in a private health care setting in Brazil.MATERIALS AND METHODSWe ...
Rodrigo Afonso da Silva Sardenberg, Mariana Ribeiro Monteiro, Cinthia Leite Frizzera Borges Bognar, Victor Braga Gondim Teixeira, Rodrigo de Carvalho Moreira, Henry Sznejder, Riad Naim Younes   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Exploring the relationship between knowledge management and organizational learning via fuzzy cognitive mapping [PDF]

, 2008
The normative literature within the field of Knowledge Management has tended to concentrate on techniques and methodologies for codifying knowledge. Similarly, the literature on organizational learning, focuses on aspects of those knowledge that are ...
Irani, Z, Sharif, A M
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Leveraging household survey data to measure barriers to health services access in the Americas

Revista Panamericana de Salud Pública, 2020
Ernesto Báscolo, Natalia Houghton, Amalia Del Riego   +2 more
doaj   +1 more source

Sustaining measles and rubella elimination through the Regional Monitoring and Re-Verification Commission in the Americas

Revista Panamericana de Salud Pública
The elimination of endemic rubella and measles transmission in the Region of the Americas was verified by the Pan American Health Organization’s (PAHO) Regional Verification Commission in 2015 and 2016, respectively.
Jon K. Andrus, Jose I. Santos, Tracy Evans Gilbert, Marilda Siqueira, Angela Gentile, Jorge Boshell, Susan Reef   +6 more
doaj   +1 more source