Results 131 to 140 of about 540,321 (312)
Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2
Nature CommunicationsMembers of the proteinase-activated receptor (PAR) subfamily of G protein-coupled receptors (GPCRs) play critical roles in processes like hemostasis, thrombosis, development, wound healing, inflammation, and cancer progression.
Zongyang Lyu +10 more
doaj +1 more source
In the shadow of the ICC: Colombia and international criminal justice [PDF]
The report of the expert conference examining the nature and dynamics of the role of the International Criminal Court in the ongoing investigation and prosecution of atrocious crimes committed in Colombia.
Cantor, David +5 more
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Organic Citrus: Challenges in Production and Trade [PDF]
, 2005 Organic citrus still is a niche and makes about 1-2% of the global citrus production. However, it is increasing year-by-year in parallel with the increasing demand for organic products.
Kilcher, Lukas
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, 2002 In the first person narrative of 'America! America!' the events of September 11th are 'recalled' by a dying female voice experiencing 'jouissance'- a little death within a greater death, a ravishment of grief and regret for her own death and that of others. Both the text itself (written in response to September 11th),and its subsequent development as a
openaire
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Aportes para la Integración Latinoamericana, 2017 Nosotras y Nosotros, las Jefas y los Jefes de Estado y de Gobierno de los países democráticos de las Américas, guiados por un espíritu renovado de cooperación, integración y solidaridad, nos hemos reunido en Puerto España en la Quinta Cumbre de las ...
Cumbre de Las Américas
doaj
Do Currency Regimes Matter in the 21st Century? An Overview [PDF]
This paper selectively reviews the recent literature on currency regimes in Europe, the Americas, and East Asia. We argue that, given the global interdependence among today's economies, currency regimes should always be evaluated in relation to monetary ...
Fujiki, Hiroshi, Otani, Akira
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source