Results 151 to 160 of about 540,321 (312)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
The Economic Impact of a U.S. Slowdown on the Americas [PDF]
This paper shows that the U.S.'s biggest trading partners in the Americas will likely see a significant loss in exports and GDP as the U.S. economy slows. Countries less reliant on the U.S. market will not be as negatively impacted.
John Schmitt +2 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Oral health in the Americas: progress, gaps, and the path to universal coverage. [PDF]
Lancet Reg Health AmThe Lancet Regional Health-Americas.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Language matters: advancing linguistic equity in health research in the Americas. [PDF]
Lancet Reg Health AmConnors K, Lara-Arevalo J.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Diphtheria and pertussis outbreaks in the Americas: a scoping review of epidemiology, vaccination trends and control strategies, 2013-2024. [PDF]
BMJ Public HealthJean Baptiste AE +6 more
europepmc +1 more source