Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Leveraging household survey data to measure barriers to health services access in the Americas
Revista Panamericana de Salud Pública, 2020 Ernesto Báscolo +2 more
doaj +1 more source
Sustained increase in measles cases prompts the Americas to strengthen surveillance, rapid response and vaccination efforts. [PDF]
Rev Panam Salud PublicaPan American Health Organization.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
El aumento sostenido de los casos de sarampión lleva a que la Región de las Américas fortalezca la vigilancia, la respuesta rápida y la vacunación. [PDF]
Rev Panam Salud PublicaOrganización Panamericana de la Salud.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Regional variations and trends in hemophilia prevalence: A global analysis with future projection. [PDF]
PLOS Glob Public HealthMothashin M +5 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Tree cover loss in the Americas: a critical indicator linking climate mitigation and planetary health. [PDF]
Lancet Reg Health AmRojas-Rueda D +2 more
europepmc +1 more source
Dreaming of Freedom in the Americas: Four Minds and A Name [PDF]
The full text of the inaugural lecture of the Institute for the Study of the Americas, given by Professor James Dunkerley on 25 October ...
Dunkerley, James
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