Results 231 to 240 of about 618,010 (298)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Ex vivo and computational investigation of corneal iontophoresis to enhance penetration of high-molecular-weight compounds: a study using albumin as a model molecule. [PDF]

Sci Rep
Mohamed AK, Mahmoud SS, Elshibly SM, Kamal GM.   +3 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Nanoassembly-enabled aqueous solid-phase peptide synthesis (ASPPS): a practical DMF-free approach based on the Fmoc strategy. [PDF]

RSC Adv
Hojo K, Nonaka A, Manabe Y, Rentier C, Mehrotra A, Hioki K, Kunishima M.   +6 more
europepmc   +1 more source

The Comparison between Different Extracellular Vesicle Isolation Methods by AFM-IR Nanospectroscopy. [PDF]

Anal Chem
da Silva JV, Berenguel O, Neres-Santos RS, Martinho HDS, Carneiro-Ramos MS.   +4 more
europepmc   +1 more source

Residue-Specific Signatures of Structural Water Identified by Dissolution Dynamic Nuclear Polarization with UV-Generated Radicals. [PDF]

Angew Chem Int Ed Engl
Hecker F, Teilum K, Capozzi A, Lerche MH.   +3 more
europepmc   +1 more source

Studying Collagen Architecture in Solution by Raman Optical Activity Spectroscopy. [PDF]

Anal Chem
Kessler J, Šebestík J, Šafařík M, Pelc R, Bouř P, Wu T.   +5 more
europepmc   +1 more source

Charge-Transfer Complexes and Fluorescence Modulation in Amide- and Carboxy-Substituted 2‑Phenyl-1,3,2-benzodiazaboroles. [PDF]

ACS Omega
Green J, Blake B, Rash A.
europepmc   +1 more source

Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy - a cadaveric study. [PDF]

Biomed Opt Express
Hosseini M, Afrin S, Yosick A, Schenker E, Awad H, Berger AJ.   +5 more
europepmc   +1 more source

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Amide–Amide Hydrogen Bonding. Semirubin Amides

Monatshefte für Chemie - Chemical Monthly, 2006
Semirubins are analogs for one-half of the bilirubin structure and capable of intramolecular hydrogen bonding. Semirubin amides of ammonia and primary amines are also capable of intramolecular hydrogen bonding. From a combination of spectroscopic methods (1H NMR, NOE, and VPO), the primary amide is found to engage very effectively in intramolecular ...
Nicholas T. Salzameda, David A. Lightner
openaire   +1 more source