Results 21 to 30 of about 48,089 (168)

Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study

Molecules, 2023
The severity of infectious diseases associated with the resistance of microorganisms to drugs highlights the importance of investigating bioactive compounds with antimicrobial potential.
Mayara Castro de Morais, Edeltrudes de Oliveira Lima, Yunierkis Perez-Castillo, Damião Pergentino de Sousa   +3 more
doaj   +1 more source

An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide

Beilstein Journal of Organic Chemistry, 2013
A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides.
Liquan Tan, Peng Zhou, Cui Chen, Weibing Liu   +3 more
doaj   +1 more source

AMIDES ISOLATED FROM THE LEAVES OF Piper tuberculatum Jacq. (Piperaceae) WITH ACETYLCHOLINESTERASE INHIBITION AND LARVICIDAL ACTIVITY AGAINST Aedes aegypti [PDF]

Química Nova
Piper tuberculatum Jacq. is known to be a promising source of amides, which have shown remarkable biological activities. In this study, a phytochemical investigation of the leaves of P.
Brenda R. C. Leocadio, Taynara S. Vale, Felipe M. A. da Silva, João V. C. O. Santos, Sergio M. Nunomura, André C. de Oliveira, Ingrity S. C. Sá, Rosemary A. Roque, Ana Paula A. Castro, Magno P. Muniz, Rita C. S. Nunomura   +10 more
doaj   +1 more source

Progress on Cassaine-Type Diterpenoid Ester Amines and Amides ( Alkaloids)

Natural Product Communications, 2006
The structures, spectral characteristics, and bioactivities of 39 natural cassaine-type diterpenoid ester amines and amides (Erythrophleum alkaloids) and 31 synthetic analogues are reviewed.
Jing Qu, Shishan Yu, Wenzhao Tang, Yunbao Liu, Yue Liu, Jing Liu   +5 more
doaj   +1 more source

Preparation, Characterization and Evaluation of Some New Amides as Antimicrobial Agents

Hittite Journal of Science and Engineering, 2020
The some new amide derivatives 1(a-c) and, 2d were synthesized by the two-step N-acylation of 4-nitroaniline or heterocyclic amine derivatives with acyl chlorides.
Aysel Veysioğlu, Şükriye Çakmak
doaj   +1 more source

Alkylation of N-substituted-2-phenylacetamides [PDF]

Journal of the Serbian Chemical Society, 2004
Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used
Mijin Dušan Ž., Mišić-Vuković Milica M., Petrović Slobodan D.   +2 more
doaj   +1 more source

New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

Molecules, 2012
Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a–e which differ from sorafenib in their amide part.
Branka Zorc, Jos Vanderleyden, Marijeta Kralj, Mariya Petrova, Jan Balzarini, Ana-Matea Mikecin, Zrinka Rajić, Maja Crkvenčić, Željka Babić   +8 more
doaj   +1 more source

Metabolites Identification of Bioactive Compounds Daturataturin A, Daturametelin I, N-Trans-Feruloyltyramine, and Cannabisin F From the Seeds of Datura metel in Rats

Frontiers in Pharmacology, 2018
Datura metel L. is a widely used traditional herbal medicine, and withanolides and amides are the two groups of main bioactive constituents in Datura metel seeds.
Silun Xu, Yan Liu, Ling Xiang, Fan Zhou, Hongyu Li, Yongjian Su, Xinyi Xu, Qi Wang   +7 more
doaj   +1 more source

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

Molecules, 2010
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized
Dong-Sheng Ma, Hua Zhang, Wei Wang, Lijuan Liu, Chaoyu Wang   +4 more
doaj   +1 more source

Dielectric Relaxation Studies of Hydrogen Bonded Complexes of Benzamide and Acetamide with Halogenated Phenols Using X-band Microwave Frequency

ASEAN Journal on Science and Technology for Development, 2021
At 308 K, using a 9.37 GHz dielectric relaxation setup, dielectric studies of hydrogen bonded complexes of benzamide and acetamide with 4-fluorophenol, 4-bromophenol, 4-chlorophenol, and 4-iodophenol in benzene were performed.
A. Aathif Basha, F. Liakath Ali Khan
doaj   +1 more source