Results 41 to 50 of about 196,786 (315)

Septic encephalopathy: does inflammation drive the brain crazy?

Brazilian Journal of Psychiatry, 2014
Sepsis and the multiorgan dysfunction syndrome are among the most common reasons for admission to an intensive care unit, and are a leading cause of death.
Felipe Dal-Pizzol, Cristiane D. Tomasi, Cristiane Ritter   +2 more
doaj   +1 more source

Sympathomimetic Amines [PDF]

Anaesthesia and Intensive Care, 1980
The autonomic nervous system may play an important role in tissue autoregulation as the neurohumoral transmission process has been shown to constitute the final common pathway by which the effects of many physiological and pharmacological substances are mediated.
openaire   +2 more sources

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

Palladium-Catalyzed Tandem C(sp³)‑H Insertion Cyclization of 2‑(2-Vinylarene)acetonitriles with Isocyanides to Access Naphthalen-2-amines

, 2023
A Pd-catalyzed cyclization reaction of 2-(2-vinylarene)acetonitriles and isocyanides has been documented. Various naphthalen-2-amines were obtained in moderate to good yields under mild conditions.
Huishu Lin (16826691), Haitao Tang, Yongzhou Pan, Wanguo Yu (8307006), Yingming Pan (8458044), Xu Wang (28596), Jinping Fu (646096), Xu Wang, Yi Yi (1488118), Yi Yi, Wanguo Yu, Huishu Lin, Yongzhou Pan (16826694), Haitao Tang (7026479), Yingming Pan, Jinping Fu   +15 more
core   +1 more source

Efficient and Selective N-Dimethylation of Amines with Functional Aldehydes Catalysed by Ru Nanoparticles Heterogeneous Catalyst

, 2021
N-methylated amines are essential bioactive compounds and have been widely used in the fine and bulk chemical industries, as well as in pharmaceuticals, agrochemicals, and dyes.
Jianguo, Liu, Longlong, Ma, Xiang, Wu, Yanpei, Song   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Catalytic Asymmetric Decarboxylative Mannich Reaction of Malonic Acid Half Esters with Cyclic Aldimines: Access to Chiral β‑Amino Esters and Chroman-4-amines

, 2016
An enantioselective decarboxylative Mannich reaction of malonic acid half esters (MAHEs) with cyclic aldimines has been accomplished by employing the copper­(I)/(R,R)-Ph-Box complex as chiral catalyst.
Jing Nie (139250), Jun-An Ma (1393726), Heng-Xia Zhang (1393732), Chun-Man Jia (3103830)   +3 more
core   +2 more sources

Biogenic amines disease in dairy products

, 2022
openLe ammine biogene sono composti tossici prodotti da microrganismi come batteri, lieviti e muffe come risultato della decarbossilazione di alcuni amminoacidi.
CHINELLO, MANUEL
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Organic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined

Toxins, 2018
Small metabolites and peptides in 17 snake venoms (Elapidae, Viperinae, and Crotalinae), were quantified using liquid chromatography-mass spectrometry. Each venom contains >900 metabolites and peptides.
Alejandro Villar-Briones, Steven D. Aird   +1 more
doaj   +1 more source