Amino acyl tRNA synthetase inhibitors is therapeutics for gliomas at sub nanomolar concentrations [PDF]
African Journal of Biotechnology, 2020 Glioblastoma is the most malignant and fatal of all primary brain tumors. Each year in the United States, about 22,000 cases of glioma are diagnosed and about 70% of these patients die. The current treatment modality options available for glioma patients are limited to temozolomide, radiation, and surgery.
C. Asuzu Peace, U. Awah Chidiebere
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Syndrome in question: antisynthetase syndrome (anti-PL-7) [PDF]
Anais Brasileiros de Dermatologia, 2016 : Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS).
Ana Cláudia Cavalcante Esposito +2 more
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High molecular mass amino acyl‐tRNA synthetase complexes in eukaryotes [PDF]
FEBS Letters, 1982 Aminoacyl-t RNA synthetases (AARS) are enzymes which play an indispensable role in protein biosynthe- sis by catalyzing the formation of aminoacyl-tRNA from amino acid, the cognate tRNA, and ATP by highly selective intermolecular interactions [57]. Joachimiak and Barciszewski [41] have provided an extensive compilation of the properties of the amino ...
Dang, Chi V. +2 more
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Codon Usage, Amino Acid Usage, Transfer RNA and Amino-Acyl-tRNA Synthetases in Mimiviruses [PDF]
Intervirology, 2013 Mimiviruses are giant viruses that infect phagocytic protists, including <i>Acanthamoebae</i> spp., which were discovered during the past decade. They are the current record holder among viruses for their large particle and genome sizes. One group is composed of three lineages, referred to as A, B and C, which include the vast majority of ...
Philippe, Colson +3 more
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SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]
, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F +8 more
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PLoS ONE, 2014 In Toxoplasma gondii, as in other eukaryotes, a subset of the amino-acyl-tRNA synthetases are arranged into an abundant cytoplasmic multi-aminoacyl-tRNA synthetase (MARS) complex.
Jason M van Rooyen +8 more
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An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]
, 1996 A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N. +7 more
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Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2005 The amoeba-infecting Mimivirus is the largest known double-stranded DNA virus, with a 400 nm particle size, comparable to that of mycoplasma. The complete sequence of its 1.2 Mbp genome has recently been determined [Raoult et al. (2004), Science, 306, 1344-1350] and revealed numerous genes that were not expected to be found in a virus, such as genes ...
Chantal, Abergel +5 more
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Síndrome antissintetase anti-Jo-1 Anti-Jo-1 antisynthetase syndrome
Revista Brasileira de Reumatologia, 2010 OBJETIVO: Devido à escassez de estudos populacionais, apresentamos um estudo epidemiológico em síndrome antissintetase anti-Jo-1 (SAS). PACIENTES E MÉTODOS: Estudo coorte retrospectivo realizado em um centro de 1980 a 2010.
Samuel Katsuyuki Shinjo +1 more
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Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
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