Results 121 to 130 of about 6,864 (161)

Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma. [PDF]

Nat Commun
Zhang H, Wang Z, Zhao Y, Deng X, Zhang J, Shang F, Zhang H, Liu Y, Wang H, Yang Y, Lin H, Zhang B, Liu C, Guo F, Zhang R, Yuan Q, Feng Y, Luo SZ, Chen WD, Wang YD.   +19 more
europepmc   +1 more source

Asparaginyl-tRNA synthetase (NARS1) variants implicated in dominant neurological phenotypes display dominant-negative properties. [PDF]

HGG Adv
Peeples SM, Blake K, Sutton BLM, Konyukh M, Züchner S, Stojkovic T, Baets J, Antonellis A.   +7 more
europepmc   +1 more source

Human disease-causing missense genetic variants are enriched in the evolutionarily ancient domains of the cytosolic aminoacyl-tRNA synthetase proteins. [PDF]

IUBMB Life
Turvey AK, Cavalcanti ARO.
europepmc   +1 more source

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[Methylation of liver tissue amino acyl-tRNA-synthetases under different experimental conditions].

Ukrains'kyi biokhimichnyi zhurnal, 1977
Incorporation of 14CH3-methionine into the total preparations of aminoacyl-tRNA-synthetases (ARSases) of the rat liver was studied under conditions of X-irradiation as well as with administration of neostigmine methylsulphate and nicotinic acid to the normal and irradiated animals.
R P, Vinogradova, G N, Ishimova, V V, Samiĭlenko   +2 more
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Defining the Determinants for Dual Targeting of Amino Acyl-tRNA Synthetases to Mitochondria and Chloroplasts

Journal of Molecular Biology, 2009
Most of the organellar amino acyl-tRNA synthetases (aaRSs) are dually targeted to both mitochondria and chloroplasts using dual targeting peptides (dTPs). We have investigated the targeting properties and domain structure of dTPs of seven aaRSs by studying the in vitro and in vivo import of N-terminal deleted constructs of dTPs fused to green ...
Berglund, A.K., Pujol, C., Duchene, A.M., Glaser, E.   +3 more
openaire   +3 more sources

Sizes of two amino acyl-tRNA synthetase complexes from E. coli with their cognate tRNAs

Biochemical and Biophysical Research Communications, 1979
Abstract The complexes of valyl-tRNA synthetase with tRNAIVal and arginyl-tRNA synthetase with tRNAIIArg from E. coli were studied by light scattering measurements and analytical ultracentrifugation of concentrations as low as 40 μg/ml. The molecular weights determined from these studies were 260,000 ± 2,000 for the valyl-tRNA synthetase·tRNA ...
J, Kuhlmeyer, H H, Paradies
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Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications

2013
In this chapter we describe aminoacyl-tRNA synthetase (aaRS) production of dinucleotide polyphosphate in response to stimuli, their interaction with various signaling pathways, and the role of diadenosine tetraphosphate and diadenosine triphosphate as second messengers.
Sagi, Tshori, Ehud, Razin, Hovav, Nechushtan   +2 more
openaire   +2 more sources

Glycosidic bond cleavage of 5-fluoro-2′-deoxyuridine and 5-fluorouridine by amino acyl-tRNA synthetases

Biochemical and Biophysical Research Communications, 1990
Lysyl-tRNA synthetase isolated from rat liver cleaves glycosidic bond of 5-Fluorouridine and 5-Fluoro-2'-deoxyuridine to generate 5-Fluorouracil. The generation of 5-Fluorouracil was monitored by cellulose thin layer chromatography and by spectrophotometry. The enzyme was found to be 1.4 fold more efficient in cleaving the glycosidic bond of 5-Fluoro-2'
Kumar, Madan A, Nayak, R
openaire   +2 more sources

Studies on the regulation of the branched chain amino acyl-tRNA synthetases of the fungusNeurospora crassa

Wilhelm Roux's Archives of Developmental Biology, 1980
The specific activities of the branched chain amino acyl-tRNA synthetases from the cytosolic and mitochondrial fractions ofN. crassa were low in dormant conidia and increased during germination, reaching a maximum 8 h after inoculation. This stage of development is characterised by high rates of many other cellular activities.The increases in activity ...
I V, Economidis, R P, Wagner
openaire   +2 more sources