Results 131 to 140 of about 6,864 (161)

Inhibition of amino acyl tRNA synthetase activity by copper complexes of two metal binding ligands isatin beta-thiosemicarbazone and 8-hydroxyquinoline

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
Copper complexes of N-methyl isatin beta-thiosemicarbazone, 1-formyl isoquinoline thiosemicarbazone and thiosemicarbazide inhibit amino acyl tRNA synthetase activity. Copper complexes of 8-hydroxyquinoline and 8-mercaptoquinoline also inhibit. The 1 : 1 ligand-metal complex is significantly more active than the 2 : 1 complex.
W, Rohde, B, Cordell, R, Webster, W, Levinson   +3 more
openaire   +2 more sources

Amino-acyl tRNA synthetases associated with leukodystrophy

Amino-acyl tRNA synthetases (ARSs) are enzymes that catalyze the amino-acylation reaction of a specific amino acid and its cognate tRNA and are divided into type 1 (cytosolic) and type 2 (mitochondrial). In this chapter leukodystrophies caused by tRNA synthetase deficiencies are reviewed.
Engelen, Marc, van der Knaap, Marjo S., Wolf, Nicole I.   +2 more
openaire   +4 more sources

[Amino acyl tRNA synthetase complexes in rabbit liver in experimental myocardial infarction].

Ukrainskii biokhimicheskii zhurnal (1978), 1983
The composition of high-molecular complexes of aminoacyl-tRNA-synthetases (ARSase) from the rabbit liver was studied on the first day after reproduction of the experimental myocardium infarction. The studies revealed an increase in the glutamyl-, leucyl-, lysyl- and a decrease in the glycyl- and seryl-tRNA-synthetase activities and redistribution of ...
L L, Ivanov, L Iu, Lukoshiavichius, M I, Kovalenko, O D, Bagdonaĭte, A V, Lekis   +4 more
openaire   +1 more source

The broad clinical spectrum of amino acyl tRNA synthetase mutations.

2015
Mitochondrial disease is a very heterogeneous group of conditions, usually characterized by a faulty OXPHOS system on the metabolic level, and (a multi) organ failure as the clinical phenotype. These disorders collectively affect at least 1 in 5 000 individuals of the population, and are incurable with treatment merely supportive.
Seneca, Sara, D'hooghe, M., Van Der Knaap, Marjo, Stouffs, Katrien, Jonckheere, An, Vancoster, R., Vanlander, A., Smet, Joél, De Meirleir, Linda   +8 more
openaire   +1 more source

[Interaction of amino acyl-tRNA-synthetases from the rabbit liver with RNA and polyanions].

Biokhimiia (Moscow, Russia), 1988
The interaction of aminoacyl-tRNA synthetase with RNA and polyanions was studied. The inhibition of the enzymes by polyU, polyI and heparin was demonstrated. It was found that this interaction is of limited specificity and is typical of single-stranded RNAs which possess no orderly secondary structure as well as of other polyanions possessing similar ...
A D, Vol'fson, Iu A, Motorin, A Iu, Tsygankov, A F, Orlovskiĭ, K L, Gladilin   +4 more
openaire   +1 more source

Studies on Amino-acyl-tRNA Synthetases from Pseudomonas aeruginosa* II. Properties of Leucyl-, and Tyrosyl-tRNA Synthetases

The Journal of Biochemistry, 1968
Y, Kaziro, Y, Takahashi, N, Inoue
openaire   +2 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Novel (Ovario) Leukodystrophy Related to a Mutation on Mitochondrial Alanine Amino Acyl tRNA Synthetase Gene Misdiagnosed as Multiple Sclerosis (P6.145)

Neurology, 2016
Dominique Rosales, Lauren Krupp
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly