Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA-Protein Interactions. [PDF]
Angew Chem Int Ed EnglThis review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Lundrigan E +3 more
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Cell Reports, 2017 Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis
Christopher M. Webster +8 more
doaj +1 more source
BMC Microbiology, 2009 Background Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial survival or death at supra ...
Proctor Richard A +5 more
doaj +1 more source
Naturally Occurring Isoleucyl-tRNA Synthetase without tRNA-dependent Pre-transfer Editing [PDF]
, 2016 Isoleucyl-tRNA synthetase (IleRS) is unusual among aminoacyl-tRNA synthetases in having a tRNA-dependent pre-transfer editing activity. Alongside the typical bacterial IleRS (such as Escherichia coli IleRS), some bacteria also have the enzymes (eukaryote-
Bilus, M +5 more
core +1 more source
Pyrophosphate-Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation. [PDF]
, 2016 UnlabelledSyntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consuming ...
Erde, Jonathan +17 more
core +6 more sources
The aminoacyl-tRNA synthetases of Drosophila melanogaster. [PDF]
, 2015 Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation ...
Gharib, Walid H +3 more
core +5 more sources
4-Phosphopantethein Transfer in Bacillus subtilis und Pseudomonas aeruginosa sowie Grundlagen zur gerichteten Proteinevolution von Adenylierungsdomänen der Nichtribosomalen Peptidsynthetasen [PDF]
, 2003 Carrier Proteine (CP) werden in unterschiedlichen prokaryontischen und eukaryontischen Synthesesystemen als Transporteinheiten für die Syntheseintermediate eingesetzt.
Finking, Robert +1 more
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Role of the Bifunctional Aminoacyl-tRNA Synthetase EPRS in Human Disease [PDF]
, 2020 Aminoacyl-tRNA synthetases (AARS) are a class of enzymes that catalyze the charging of tRNAs with cognate amino acids, a critical step that contributes to the fidelity of protein synthesis.
Kudlapur, Nathan
core
Compound heterozygous mutations in glycyl-tRNA synthetase are a proposed cause of systemic mitochondrial disease [PDF]
, 2014 Background Glycyl-tRNA synthetase (GARS) is an aminoacyl-tRNA synthetase (ARS) that links the amino acid glycine to its corresponding tRNA prior to protein translation and is one of three bifunctional ARS that are active within ...
Amanda Smith +9 more
core +1 more source
Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea [PDF]
, 2010 Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation.
Rother, Michael, Krzycki, Joseph A.
core +1 more source