Results 21 to 30 of about 6,864 (161)
Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases. [PDF]
, 2014 International audienceCyclodipeptide synthases form cyclodipeptides from two aminoacyl transfer RNAs. They use a ping-pong mechanism that begins with transfer of the aminoacyl moiety of the first aminoacyl tRNA onto a conserved serine, yielding an ...
Belin, Pascal +7 more
core +3 more sources
The FASEB Journal, 2019 The site‐specific incorporation of non‐standard and novel amino acid structures enabled by Genetic Code Expansion (GCE) provides access to new avenues of protein research allowed by engineering diverse functionality into proteins. At its core, GCE requires the engineering of an orthogonal amino acyl‐tRNA synthetase/tRNA cognate pair that can function ...
Jenna N. Beyer +3 more
openaire +1 more source
FabR regulates Salmonella biofilm formation via its direct target FabB [PDF]
, 2016 Background: Biofilm formation is an important survival strategy of Salmonella in all environments. By mutant screening, we showed a knock-out mutant of fabR, encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm ...
De Coster, David +8 more
core +4 more sources
FlyAmino acyl-tRNA synthetases perform diverse non-canonical functions aside from their essential role in charging tRNAs with their cognate amino acid. The phenylalanyl-tRNA synthetase (PheRS/FARS) is an α2β2 tetramer that is needed for charging the tRNAPhe
Dominique Brunßen, Beat Suter
doaj +1 more source
Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei [PDF]
, 2014 International audienceCyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of three CDPSs have been determined and all show a Rossmann-fold domain similar ...
Arthur, Michel +7 more
core +4 more sources
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To summarize the clinical manifestations and genetic characteristics of patients with Charcot-Marie-Tooth disease (CMT) caused by ARSs gene variation. Methods and Results A total of 12 probands with clinical diagnosis of CMT were selected from
LI Yi-qing +5 more
doaj +1 more source
LifeHow Nature discovered genetic coding is a largely ignored question, yet the answer is key to explaining the transition from biochemical building blocks to life. Other, related puzzles also fall inside the aegis enclosing the codes themselves. The peptide
Charles W. Carter
doaj +1 more source
Template-directed biopolymerization: tape-copying Turing machines
, 2012 DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core +1 more source
Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons [PDF]
, 2016 In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein synthesis while concomitantly promoting preferential translation of specific transcripts associated with stress adaptation.
Baird, Thomas D. +2 more
core +1 more source
Deriving enzymatic and taxonomic signatures of metagenomes from short read data [PDF]
, 2010 Background We propose a method for deriving enzymatic signatures from short read metagenomic data of unknown species. The short read data are converted to six pseudo-peptide candidates.
Uri Weingart +3 more
core +2 more sources