Results 1 to 10 of about 342 (96)

L-Lysine α-Oxidase: Enzyme with Anticancer Properties

Pharmaceuticals, 2021
L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO.
E. Lukasheva, G. Babayeva, S. Karshieva, D. Zhdanov, V. Pokrovsky   +4 more
semanticscholar   +1 more source

Cyclic 68Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2

Journal of Nuclear Medicine, 2021
Visual Abstract In this study, we developed angiotensin-converting enzyme 2 (ACE2)–specific, peptide-derived 68Ga-labeled radiotracers, motivated by the hypotheses that ACE2 is an important determinant of severe acute respiratory syndrome coronavirus 2 ...
Matthew F. L. Parker, J. Blecha, O. Rosenberg, Michael A. Ohliger, R. Flavell, D. M. Wilson   +5 more
semanticscholar   +1 more source

A High-Efficiency Artificial Synthetic Pathway for 5-Aminovalerate Production From Biobased L-Lysine in Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2021
Bioproduction of 5-aminovalerate (5AVA) from renewable feedstock can support a sustainable biorefinery process to produce bioplastics, such as nylon 5 and nylon 56.
Jie Cheng, Wenying Tu, Zhou Luo, Xing-Hua Gou, Qiang Li, Dan Wang, Jing-Wen Zhou   +6 more
semanticscholar   +1 more source

Structural basis of strict substrate recognition of l‐lysine α‐oxidase from Trichoderma viride

Protein Science, 2020
l‐Lysine oxidase (LysOX) is a FAD‐dependent homodimeric enzyme that catalyzes the oxidative deamination of l‐lysine to produce α‐keto‐ε‐aminocaproate with ammonia and hydrogen peroxide.
H. Kondo, M. Kitagawa, Y. Matsumoto, Masaya Saito, Marie Amano, S. Sugiyama, T. Tamura, H. Kusakabe, K. Inagaki, K. Imada   +9 more
semanticscholar   +1 more source

Spontaneous and pronase‐induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines

The Journal of Pathology, Volume 229, Issue 3, Page 390-399, February 2013., 2013
Abstract A subgroup of HER2‐overexpressing breast tumours co‐expresses p95$^{{\rm{HER2}}}$, a truncated HER2 receptor that retains a functional HER2 kinase domain but lacks the extracellular domain, thus impairing trastuzumab binding. We evaluated p95$^{{\rm{HER2}}}$ expression in 99 frozen breast carcinoma samples by western blot analysis.
Daniele Recupero, Lorenzo Daniele, Caterina Marchiò, Luca Molinaro, Isabella Castellano, Paola Cassoni, Alberto Righi, Filippo Montemurro, Piero Sismondi, Nicoletta Biglia, Giuseppe Viale, Mauro Risio, Anna Sapino   +12 more
wiley   +1 more source

Oat Protects against Diabetic Nephropathy in Rats via Attenuating Advanced Glycation End Products and Nuclear Factor Kappa B

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Oat, a rich source of soluble fiber, was considered to have a possible preventive effect on the progression of diabetic nephropathy. The present study aimed to assess this preventive activity in a rat model of diabetic nephropathy. Adult Wister rats were injected by streptozotocin (65 mg/kg).
Abdulrahman L. Al-Malki, Ravirajsinh Jadeja   +1 more
wiley   +1 more source

Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2

bioRxiv, 2020
In this study, we developed ACE2-specific, peptide-derived 68Ga-labeled radiotracers, motivated by the hypotheses that (1) ACE2 is an important determinant of SARS-CoV-2 susceptibility, and (2) that modulation of ACE2 in COVID-19 drives severe organ ...
Matthew F. L. Parker, J. Blecha, O. Rosenberg, Michael A. Ohliger, R. Flavell, David M. Wilson   +5 more
semanticscholar   +1 more source

Production of nonnatural straight-chain amino acid 6-aminocaproate via an artificial iterative carbon-chain-extension cycle

bioRxiv, 2019
Bioplastics produced from microbial source are promising green alternatives to traditional petrochemical-derived plastics. Nonnatural straight-chain amino acids, especially 5-aminovalerate, 6-aminocaproate and 7-aminoheptanoate are potential monomers for
Jie Cheng, Ge Hu, Yanqin Xu, M. P. Torrens-Spence, Xiao-Hua Zhou, Dan Wang, Jing-Ke Weng, Qin-Hong Wang   +7 more
semanticscholar   +1 more source

Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins.

Journal of Lipid Research, 2001
Lipoprotein [a] (Lp[a]) is a cholesterol-rich lipoprotein resembling LDL to which a large polymorphic glycoprotein, apolipoprotein [a] (apo[a]), is covalently coupled.
J. Gaubatz, R. Hoogeveen, A. S. Hoffman, Karima G. Ghazzaly, H. Pownall, J. Guevara, M. Koschinsky, J. Morrisett   +7 more
semanticscholar   +1 more source

Novel Degradation Pathway of Glycated Amino Acids into Free Fructosamine by a Pseudomonas sp. Soil Strain Extract (*)

Journal of Biological Chemistry, 1995
A Pseudomonas sp. soil strain, selected for its ability to grow on -(1-deoxyfructosyl) aminocaproic acid, was induced to express a membrane-bound enzymatic activity which oxidatively degrades Amadori products into free fructosamine. Apparent K values for
C. Gerhardinger, M. Marion, A. Rovner, M. Glomb, V. Monnier   +4 more
semanticscholar   +1 more source