Results 41 to 50 of about 4,991,140 (249)

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

Frontiers in Pharmacology, 2020
Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR),
Laura Dhondt, Siska Croubels, Peter De Paepe, Steven C. Wallis, Saurabh Pandey, Jason A. Roberts, Jason A. Roberts, Jason A. Roberts, Jason A. Roberts, Jason A. Roberts, Jeffrey Lipman, Jeffrey Lipman, Jeffrey Lipman, Pieter De Cock, Pieter De Cock, Pieter De Cock, Mathias Devreese   +16 more
doaj   +1 more source

Net Portal Appearance of Amino Acids in Iberian and Landrace Pigs Fed Different Protein Content in the Diet

Animals, 2023
Iberian pigs have low rates of muscle protein deposition compared with modern breeds. Differences in net portal appearance (NPA) of amino acids (AA) might partially explain that. NPA of AA was measured in six Iberian and six Landrace gilts (28 kg) fitted
Manuel Lachica, José Miguel Rodríguez-López, Lucrecia González-Valero, Ignacio Fernández-Fígares   +3 more
doaj   +1 more source

In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions

Pharmacology Research &Perspectives, Volume 10, Issue 3, June 2022., 2022
Mechanistic static pharmacokinetic models predict that CYP450 inhibition and induction are unlikely for fenfluramine or its major metabolite norfenfluramine at doses used for seizure reduction (0.2−0.7 mg/kg/day). These results suggest minimal drug‐drug interaction perpetrator potential for either fenfluramine or norfenfluramine.
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Brian W. Ogilvie, Steven Smith, Brooks Boyd   +5 more
wiley   +1 more source

Investigation of the Effect of Lead Adsorption on Surface Modified Fish Bones

Acta Natura et Scientia, 2020
This study investigates lead (Pb) elimination of surface modified fish bones as a biogenic apatite source. Surface modification was performed with 4-Aminohippuric acid (MBA1) and 2-Thiophenecarboxaldehyde (MBA2).
Bayram Kızılkaya, Evren Tan
doaj   +1 more source

Pretherapeutic estimated glomerular filtration rate predicts development of chronic kidney disease in patients receiving PSMA‐targeted radioligand therapy

The Prostate, Volume 82, Issue 1, Page 86-96, January 1, 2022., 2022
Abstract Background Prostate‐specific membrane antigen (PSMA)‐targeted radioligand therapy (RLT) may be associated with renal toxicity. We aimed to identify predictive parameters for the development of chronic kidney disease (CKD) in patients with metastatic castration resistant prostate cancer (mCRPC) undergoing RLT.
Liam Widjaja, Thorsten Derlin, Tobias L. Ross, Frank M. Bengel, Rudolf A. Werner   +4 more
wiley   +1 more source

Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions

Pharmaceutics, 2021
Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity.
Yunzhou Fan, Zhengxuan Liang, Jinghui Zhang, Guofeng You   +3 more
doaj   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

Postprandial renal haemodynamic effects of the dipeptidyl peptidase‐4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS): A predefined substudy of a randomized, double‐blind trial

Diabetes, Obesity and Metabolism, Volume 24, Issue 1, Page 115-124, January 2022., 2022
Abstract Aim To determine the effect of the dipeptidyl peptidase‐4 inhibitor linagliptin on postprandial glomerular hyperfiltration compared with the sulphonylurea glimepiride in adults with type 2 diabetes (T2D). Materials and Methods In this predefined substudy within a randomized, double‐blind, parallel‐group, intervention trial, overweight people ...
Marcel H. A. Muskiet, Lennart Tonneijck, Mark M. Smits, Mark H. H. Kramer, D. Margriet Ouwens, Bolette Hartmann, Jens J. Holst, A. H. Jan Danser, Jaap A. Joles, Daniël H. van Raalte   +9 more
wiley   +1 more source

Analysis of urinary exosomal metabolites identifies cardiovascular risk signatures with added value to urine analysis

BMC Biology, 2020
Background Subclinical atherosclerosis may result in fatal cardiovascular (CV) events, but the underlying mechanisms and molecular players leading to disease are not entirely understood.
Marta Agudiez, Paula J. Martinez, Marta Martin-Lorenzo, Angeles Heredero, Aranzazu Santiago-Hernandez, Dolores Molero, Juan Manuel Garcia-Segura, Gonzalo Aldamiz-Echevarria, Gloria Alvarez-Llamas   +8 more
doaj   +1 more source

Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model

Pharmaceutics, 2022
Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional.
Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu   +4 more
doaj   +1 more source