HPLC estimation of iothalamate to measure glomerular filtration rate in humans [PDF]
, 2016 Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and urine.
Ashraf, Syed Salman +4 more
core +1 more source
The synthesis of some acylglycines and related oxazolones [PDF]
, 1960 No description ...
Acheson, R M +3 more
core +1 more source
Kidney & Blood Pressure Research, 2020 Background: Cr is secreted by the proximal tubules and thus Cr clearance (Ccr) can overestimate inulin clearance (Cin). However, in some cases, Ccr can even underestimate Cin. This suggests that Cr could be reabsorbed in the tubuli.
Akihiro Tsuda +7 more
doaj +1 more source
Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]
, 2017 Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan +6 more
core +3 more sources
The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs. [PDF]
Physiol RepAbstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Morse R +6 more
europepmc +2 more sources
Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. [PDF]
PLoS ONE, 2013 Glutathione (GSH) is a negatively charged tripeptide, which is a major determinant of the cellular redox state and defense against oxidative stress. It is assembled inside and degraded outside the cells and is released under various physiological and ...
Ravshan Z Sabirov +3 more
doaj +1 more source
Betaine increases net portal absorption of volatile fatty acids in Iberian pigs
Animal, 2021 Betaine is an osmolyte with the potential to increase volatile fatty acids (VFAs) production and hence improve intestinal health.The present study investigated how betaine affects portal and arterial concentrations and net portal absorption (NPA) of VFA ...
M. Lachica +5 more
doaj +1 more source
Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease [PDF]
, 2016 AIMS Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the
Delles, Christian +9 more
core +1 more source
Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance
CPT: Pharmacometrics & Systems Pharmacology, 2018 Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed.
Weize Huang, Nina Isoherranen
doaj +1 more source
Journal of Pharmacological Sciences, 2003 : The purpose of the present study was to elucidate the expression of human organic anion transporter 1 (hOAT1) and hOAT3 in the choroid plexus of the human brain and their interactions with neurotransmitter metabolites using stable cell lines ...
Mahmoud Alebouyeh +11 more
doaj +1 more source