Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. [PDF]
PLoS ONE, 2015 The role of hyperleptinemia in cardiovascular diseases is well known; however, in the renal tissue, the exact site of leptin's action has not been established.
Karina Thieme, Maria Oliveira-Souza
doaj +1 more source
Role of hydrophobic interaction in hapten-antibody binding [PDF]
, 1977 The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more
Hatase, Osamu +5 more
core +1 more source
Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations [PDF]
, 2022 Organic anion transporters (OATs) belong to a subgroup of the solute carrier 22 transporter family. OATs have a central role in xenobiotic disposition affecting the toxicokinetics of its substrates and inter-individual differences in their expression ...
Dellafiora L. +2 more
core +1 more source
Marine Drugs, 2017 This study examined the urinary excretion of tetrodotoxin (TTX) modeled in a porcine renal proximal tubule epithelial cell line, LLC-PK1. Time course profiles of TTX excretion and reabsorption across the cell monolayers at 37 °C showed that the amount of
Takuya Matsumoto +6 more
doaj +1 more source
Pharmaceutics, 2020 Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport.
Irina E. Antonescu +8 more
doaj +1 more source
Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow [PDF]
, 1989 Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow. 5-Hydroxyindoleacetic acid (5-HIAA), the major serotonin metabolite, was measured in human plasma and urine using liquid chromatography and electrochemical detection.
Déchaux, Michèle +4 more
core +1 more source
The Prolonging Action of Penicillin by Para-Aminohippuric Acid.
Experimental Biology and Medicine, 1945 Conclusions1. When the plasma para-aminohippuric acid concentration was maintained at or above 10 mg/100 ml a 3 to 6 fold elevation in penicillin plasma concentration was obtained except in two instances. 2. When the para-aminohippuric acid plasma levels were allowed to fall below 10 mg/100 ml there was no effect of that compound on the plasma ...
Erna Alture-Werber +3 more
openaire +2 more sources
Iberian pig adaptation to acorn consumption: I. Net portal appearance of metabolites [PDF]
PeerJ, 2018 Most valuable cured products from Iberian pigs come from pure bred animals raised for a final grazing-fattening period where pigs eat mainly acorns, a low protein energy rich fruit.
Ignacio Fernández-Fígares +3 more
doaj +2 more sources
Effects of patent foramen ovale in migraine: a metabolomics‐based study
The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong +15 more
wiley +1 more source
Early detection of ketoprofen-induced acute kidney injury in sheep as determined by evaluation of urinary enzyme activities [PDF]
, 2010 Peer ...
Honkavaara, Matti Juhana +9 more
core +1 more source