Results 1 to 10 of about 52 (40)

Antiprotozoal Aminosteroid Alkaloids from Buxus obtusifolia (Mildbr.) Hutch. [PDF]

Molecules
Human African Trypanosomiasis (HAT; sleeping sickness) and Malaria are life-threatening protozoan infections in tropical regions, with limited treatment options.
Justus Wambua Mukavi, Monica Cal, Marcel Kaiser, Pascal Mäser, Njogu M. Kimani, Leonidah Kerubo Omosa, Thomas J. Schmidt   +6 more
doaj   +4 more sources

Correction: Mukavi et al. Antiprotozoal Aminosteroid Alkaloids from Buxus obtusifolia (Mildbr.) Hutch. Molecules 2025, 30, 4558 [PDF]

Molecules
In the original publication [...]
Justus Wambua Mukavi, Monica Cal, Marcel Kaiser, Pascal Mäser, Njogu M. Kimani, Leonidah Kerubo Omosa, Thomas J. Schmidt   +6 more
doaj   +3 more sources

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis [PDF]

Molecules, 2018
As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena ...
Charles O Nnadi, Ngozi Justina Nwodo, Thomas J Schmidt   +2 more
exaly   +4 more sources

Seasonal, Organ-, and Location-Dependent Variations in the Alkaloid Content of Pachysandra terminalis Investigated by Multivariate Data Analysis of LC-MS Profiles [PDF]

Plants
Pachysandra terminalis (P. terminalis), a plant belonging to the Buxaceae family, is known as a great source of aminosteroid alkaloids. In a previous communication, we reported on the isolation of a variety of aminosteroids from P.
Lizanne Schäfer, Jandirk Sendker, Thomas J. Schmidt   +2 more
doaj   +2 more sources

Seasonal and Organ-Specific Variations of Alkaloids in Buxus obtusifolia (Mildbr.) Hutch: A Multivariate LC/MS Study [PDF]

Plants
Buxus obtusifolia (Mildbr.) Hutch is an evergreen shrub endemic to East Africa and is traditionally used to treat chest ailments. Our recent investigation on the dichloromethane leaf extract of this species yielded several aminosteroid alkaloids, some of
Justus Wambua Mukavi, Jandirk Sendker, Njogu M. Kimani, Leonidah Kerubo Omosa, Thomas J. Schmidt   +4 more
doaj   +2 more sources

Antiprotozoal Aminosteroids from Pachysandra terminalis [PDF]

Molecules
Trypanosoma brucei rhodesiense (Tbr) and Plasmodium falciparum (Pf) are protozoan parasites that cause severe diseases, namely, Human African Trypanosomiasis (HAT) and Malaria.
Lizanne Schäfer, Monica Cal, Marcel Kaiser, Pascal Mäser, Thomas J. Schmidt   +4 more
doaj   +2 more sources

Fascinating Furanosteroids and Their Pharmacological Profile. [PDF]

Molecules, 2023
Dembitsky VM.
europepmc   +1 more source

The Alkaloid-Enriched Fraction of Pachysandra terminalis (Buxaceae) Shows Prominent Activity against Trypanosoma brucei rhodesiense. [PDF]

Molecules, 2021
Flittner D, Kaiser M, Mäser P, Lopes NP, Schmidt TJ.   +4 more
europepmc   +1 more source

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs. [PDF]

Molecules, 2019
Nnadi CO, Ebiloma GU, Black JA, Nwodo NJ, Lemgruber L, Schmidt TJ, de Koning HP.   +6 more
europepmc   +1 more source

Blue-Print Autophagy: Potential for Cancer Treatment. [PDF]

Mar Drugs, 2016
Ruocco N, Costantini S, Costantini M.
europepmc   +1 more source