This article describes some selected results of my 30 years as an industrial researcher. During this time, I had the chance to work on many very different projects.
Peter Nesvadba
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Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes. [PDF]
The in vitro effects of six doses (2 x 10(-3) to 2 x 10(-8) M) of antimicrobial drugs that are frequently used in udder infusions on the capacity of bovine blood polymorphonuclear neutrophilic leukocytes to generate reactive oxygen species were studied ...
Burvenich, Christian +2 more
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Synthesis of a library of antiviral silvestrol analogues and development of novel methodologies in the field of radical chemistry [PDF]
The first part of this dissertation deals with the design and synthesis of silvestrol and rocaglamide derivatives exhibiting antiviral properties. These two natural products, which belong to the Flavagline group, were isolated from different species of ...
Schulz, Göran
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Oxidative stress, defined as a misbalance between the production of reactive oxygen species and the antioxidant defenses of the cell, appears as a critical factor either in the onset or in the etiology of many pathological conditions.
Nikola Babić, Fabienne Peyrot
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ESR study of the spin adducts of three analogues of DEPMPO substituted at C-4 or C-3 [PDF]
In the research program of some new derivatives of spin-trap DEPMPO (5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide) leading to various radical adducts with photogenic ESR signals, three phosphorylated pyrroline-N-oxides were studied in spin trapping.
Chalier, Florence +4 more
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Advancing Organic Chemistry Using High‐Throughput Experimentation
This review outlines major advances in the design, execution, analysis, and data management phases of high‐throughput experimentation (HTE). The limitations and potential opportunities of applying modern HTE to organic synthesis are highlighted. Abstract High‐throughput experimentation (HTE), the miniaturization and parallelization of reactions, is a ...
Reem Nsouli +2 more
wiley +2 more sources
Enhancement of trace organic contaminant degradation by crude enzyme extract from Trametes versicolor culture: Effect of mediator type and concentration [PDF]
The performance of two redox mediating compounds, namely 1-hydroxybenzotriazole (HBT) and syringaldehyde (SA), was compared in terms of enhancement of enzymatic degradation of a diverse set of 14 phenolic and 16 non-phenolic trace organic contaminants ...
Hai, Faisal Ibney +7 more
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Hydrative Aminoxylation of Ynamides: One Reaction, Two Mechanisms [PDF]
AbstractOrganic synthesis boasts a wide array of reactions involving either radical species or ionic intermediates. The combination of radical and polar species, however, has not been explored to a comparable extent. Herein we present the hydrative aminoxylation of ynamides, a reaction which can proceed by either a polar‐radical crossover mechanism or ...
Alexandre Pinto +5 more
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New Developments in Spin Labels for Pulsed Dipolar EPR [PDF]
Spin labelling is a chemical technique that enables the integration of a molecule containing an unpaired electron into another framework for study. Given the need to understand the structure, dynamics, and conformational changes of biomacromolecules ...
Concilio, M +3 more
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OH Radical Trapping with Benzoxazine nitrones: a combined computational and spectroscopic study. [PDF]
none1The hydroxyl radical addition onto 3-aryl-2H-benzo[1,4]oxazin-4-oxides spin traps yielded very persistent nitroxides. Their EPR spectra showed unusually large splitting due to the trapped OH proton, whose assignment has been possible by means of the
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