Results 101 to 110 of about 42,119 (250)

Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes

Journal of Pharmacological Sciences, 2017
Decreased brain glutamate level has emerged as a new therapeutic approach for epilepsy. This study investigated the effect and mechanism of amiodarone, an anti-arrhythmic drug with antiepileptic activity, on glutamate release in the rat hippocampus. In a
Chia Yu Chang, Chi Feng Hung, Shu Kuei Huang, Jinn Rung Kuo, Su Jane Wang   +4 more
doaj   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Amiodarone-induced thyroid dysfunction [PDF]

, 2022
Introduction. It has been found that amiodarone can cause a number of side effects, including thyroid dysfunction with an incidence of 1-27%. The incidence in the Republic of Moldova increased from 2% to 13,6% which imposed the need to analyze the ...
Gorița, Adriana
core  

Clinical Safety and Efficacy of Wenxin Keli-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Systematic Review and Meta-analysis

Frontiers in Physiology, 2018
Objectives: To evaluate possible adverse effects and efficacy of Wenxin keli (WXKL)-amiodarone combination on heart failure complicated by ventricular arrhythmia.Methods: Nine electronic literature databases (the Cochrane Library, PubMed, EMBASE, IPA ...
Rui Zheng, Rui Zheng, Guihua Tian, Guihua Tian, Qin Zhang, Qin Zhang, Lin Wu, Yanwei Xing, Hongcai Shang, Hongcai Shang   +9 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Flecainide and amiodarone interaction [PDF]

, 1986
Oral amiodarone therapy was given to seven patients already taking oral flecainide regularly. In one additional patient, administration of flecainide was temporarily discontinued when amiodarone therapy was begun, and then resumed.
Kim, Sung Soon, Shea, Patrick, Schechtman, Kenneth, Lal, Roop, Ruffy, Rodolphe   +4 more
core   +1 more source

Amiodarone Induced Epididymo-Orchitis [PDF]

, 2019
Amiodarone has a well-established and extensive side effect profile: pulmonary fibrosis, thyroid toxicity, corneal deposits, skin discoloration. However, in some rare instance, epididymitis/orchitis is a side effect of amiodarone. Amiodarone toxicity was
Panuganti, Sravan, Daly, Stephen, Khalid, Yaser, Dasu, Neethi   +3 more
core   +1 more source

Local amiodarone delivery via an extracellular collagen matrix patch to reduce new-onset postoperative atrial fibrillationCentral MessagePerspective

JTCVS Open
Objective: Systemic amiodarone is commonly used to treat new-onset postoperative atrial fibrillation (POAF) after cardiac surgery with risk for significant toxicity. This study explored the feasibility and safety of using an extracellular collagen matrix
Kevin G. Cornwell, PhD, Peter J. Jackson, PhD, Clayton A. Kaiser, MD, Clementene S. Clayton, BS, Gretel Monreal, PhD, Mark S. Slaughter, MD, Niv Ad, MD, Yiannis Monovoukas, PhD, MBA   +7 more
doaj   +1 more source

The multicellular environment of the re‐entrant circuit in post‐myocardial infarction ventricular tachycardia: Beyond fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat, Jaffar Al‐Sheikhli, Andrew M. Blanks, Joseph Mayer, Nicolas Lellouche, Tarvinder Dhanjal, Christopher O'Shea   +6 more
wiley   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source