Results 101 to 110 of about 59,816 (256)

Local amiodarone delivery via an extracellular collagen matrix patch to reduce new-onset postoperative atrial fibrillationCentral MessagePerspective

JTCVS Open
Objective: Systemic amiodarone is commonly used to treat new-onset postoperative atrial fibrillation (POAF) after cardiac surgery with risk for significant toxicity. This study explored the feasibility and safety of using an extracellular collagen matrix
Kevin G. Cornwell, PhD, Peter J. Jackson, PhD, Clayton A. Kaiser, MD, Clementene S. Clayton, BS, Gretel Monreal, PhD, Mark S. Slaughter, MD, Niv Ad, MD, Yiannis Monovoukas, PhD, MBA   +7 more
doaj   +1 more source

Clinical Safety and Efficacy of Wenxin Keli-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Systematic Review and Meta-analysis

Frontiers in Physiology, 2018
Objectives: To evaluate possible adverse effects and efficacy of Wenxin keli (WXKL)-amiodarone combination on heart failure complicated by ventricular arrhythmia.Methods: Nine electronic literature databases (the Cochrane Library, PubMed, EMBASE, IPA ...
Rui Zheng, Rui Zheng, Guihua Tian, Guihua Tian, Qin Zhang, Qin Zhang, Lin Wu, Yanwei Xing, Hongcai Shang, Hongcai Shang   +9 more
doaj   +1 more source

Methods of Assessment and Clinical Relevance of QT Dynamics [PDF]

, 2005
The dependence on heart rate of the QT interval has been investigated for many years and several mathematical formulae have been proposed to describe the QT interval/heart rate (or QT interval/RR interval) relationship. While the most popular is Bazett’s
Agata, Musialik-Lydka, Anna, Sliwinska, Beata, Sredniawa, Piotr, Jarski, Zbigniew, Kalarus   +4 more
core  

Population-Level Incidence and Monitoring of Adverse Drug Reactions with Long-term Amiodarone Therapy [PDF]

, 2017
Introduction: Amiodarone is associated with significant long-lasting adverse drug reactions (ADRs). Guidelines recommend laboratory monitoring during long-term use. However, data of compliance with laboratory monitoring are lacking.
Batcher, Berdunov, Bickford, Camm, Committee JF, Daniels, Epstein, Flynn, Goldschlager, Ioannou, January, Kim, Lafuente-Lafuente, Lewis, Mattar, Nadir, Pollak, Raebel, Raebel, Raeder, Sanoski, Stelfox, Stocks, Tjia, Vorperian   +24 more
core   +3 more sources

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes

Journal of Pharmacological Sciences, 2017
Decreased brain glutamate level has emerged as a new therapeutic approach for epilepsy. This study investigated the effect and mechanism of amiodarone, an anti-arrhythmic drug with antiepileptic activity, on glutamate release in the rat hippocampus. In a
Chia Yu Chang, Chi Feng Hung, Shu Kuei Huang, Jinn Rung Kuo, Su Jane Wang   +4 more
doaj   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Microfluidic production of amiodarone loaded nanoparticles and application in drug repositioning in ovarian cancer

Scientific Reports
Amiodarone repositioning in cancer treatment is promising, however toxicity limits seem to arise, constraining its exploitability. Notably, amiodarone has been investigated for the treatment of ovarian cancer, a tumour known for metastasizing within the ...
Asia Saorin, Gloria Saorin, Fahriye Duzagac, Pietro Parisse, Ni Cao, Giuseppe Corona, Enrico Cavarzerani, Flavio Rizzolio   +7 more
doaj   +1 more source

Association of Semaglutide Treatment With Liver Cirrhosis and Hepatocellular Carcinoma in Type 2 Diabetes: A Population‐Based Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Metabolic dysfunction–associated steatotic liver disease is common among individuals with type 2 diabetes mellitus and substantially increases the risk of liver cirrhosis and hepatocellular carcinoma. Effective therapies that improve metabolic control while preventing advanced liver outcomes are limited.
Assaf Issachar, Talish Razi, Ilya Borochov, Hadar Duskin Bitan, Ronen Arbel   +4 more
wiley   +1 more source

Goals of Care: a framework in evolution

Internal Medicine Journal, EarlyView.
Abstract The Goals of Care framework has been strongly advocated for and widely adopted in various healthcare institutions across Australia. While it has promoted awareness and perceptions around advanced care planning and treatment limitations, there remain concerns.
Benedict Tan
wiley   +1 more source