Results 241 to 250 of about 56,967 (294)
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Cochrane Database of Systematic Reviews, 2007
For many years amitriptyline has been considered one of the reference compounds for the pharmacological treatment of depression. However, new tricyclic drugs, heterocyclic compounds and selective serotonin reuptake inhibitors have been introduced on the market with the claim of a more favourable tolerability/efficacy profile.The aim of the present ...
Matthew Hotopf +2 more
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For many years amitriptyline has been considered one of the reference compounds for the pharmacological treatment of depression. However, new tricyclic drugs, heterocyclic compounds and selective serotonin reuptake inhibitors have been introduced on the market with the claim of a more favourable tolerability/efficacy profile.The aim of the present ...
Matthew Hotopf +2 more
openaire +3 more sources
Chronopharmacology of amitriptyline
Clinical Pharmacology and Therapeutics, 1983Side effects of decreased salivation and sedation were more marked when a single dose of amitriptyline was taken orally in the morning than in the evening. These dynamic differences were due to alteration in kinetics. Absorption of the drug was more rapid in the morning, although other kinetic parameters, especially total bioavailability, were ...
Shigeyuki Nakano +3 more
openaire +4 more sources
Fundamental & Clinical Pharmacology, 2020
Inflammatory bowel disease (IBD) consists of ulcerative colitis and Crohn's disease, which affects gastrointestinal tract. The immune‐mediated inflammation is mostly considered as the pathogenesis of IBD.
Pegah Dejban +4 more
semanticscholar +1 more source
Inflammatory bowel disease (IBD) consists of ulcerative colitis and Crohn's disease, which affects gastrointestinal tract. The immune‐mediated inflammation is mostly considered as the pathogenesis of IBD.
Pegah Dejban +4 more
semanticscholar +1 more source
JAMA: The Journal of the American Medical Association, 1978
Amitriptyline hydrocholride (Elavil) is frequently used in treating mild to moderate depressive states. A survey of 346 persons enrolled in a methadone maintenance program showed that 86 (25%) had admitted taking amitriptyline with the purpose of achieving euphoria. Thin-layer chromatography of random urine specimens over five months showed that 34% of
Raymond Hanbury +2 more
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Amitriptyline hydrocholride (Elavil) is frequently used in treating mild to moderate depressive states. A survey of 346 persons enrolled in a methadone maintenance program showed that 86 (25%) had admitted taking amitriptyline with the purpose of achieving euphoria. Thin-layer chromatography of random urine specimens over five months showed that 34% of
Raymond Hanbury +2 more
openaire +3 more sources
Amitriptyline and Amitriptyline-with-Perphenazine in Depression—A Retrospective Study
British Journal of Psychiatry, 1967The object of this paper is to assess, in retrospect, the relative effectiveness of amitriptyline (‘Triptizol’) and amitriptyline with perphenazine (‘Triptafen’) in the treatment of depressed patients.
C. Chacón, E. T. Downham
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A comparison of amitriptyline, vasopressin and amitriptyline with vasopressin in nocturnal enuresis
Pediatric Nephrology, 1995Forty-five children aged 6-14 years with primary nocturnal enuresis were randomised to determine whether desmopressin is more effective than amitriptyline and whether the combination of amitriptyline/desmopressin is more effective than amitriptyline or desmopressin alone.
John Burke +3 more
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Amitriptyline in childhood enuresis
Clinical Pharmacology & Therapeutics, 1966In a double‐blind, placebo‐controlled study with cross‐over, 50 outpatient enuretic children (aged 5 to 15) were treated for 8 weeks. It was found that amitriptyline in doses of 25 or 50 mg. (for children aged 12 and over) was superior clinically (P < 0.0005) to a placebo in decreasing the frequency of nights with enuresis.
Alvin F. Poussaint +2 more
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Amitriptyline‐induced ophthalmoplegia
Neurology, 1981Total external ophthalmoplegia, unresponsive to caloric stimulation, was observed in a gravid woman who had ingested approximately 1.0 to 1.5 gm of amitriptyline. The intravenous administration of 4.0 mg physostigmine salicylate (PS) produced a revival of consciousness and reflex activity but had no appreciable effect on ocular motility.
Robert Schnapper, Robert H. Spector
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Amitriptyline Abuse and Misuse
American Journal of Forensic Medicine & Pathology, 2005Deaths related to amitriptyline toxicity are relatively common and are typically related to suicidal overdose. A less well-recognized situation of amitriptyline intoxication occurs when the drug is abused for its euphorigenic effects. An amitriptyline-related death due to a mixed drug intoxication is presented.
Joseph A. Prahlow, Jeffry E. Landrum
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Contribution to the Pharmacokinetics of Amitriptyline
The Journal of Clinical Pharmacology, 1978The clinical pharmacokinetics of amitriptyline were studied in four volunteers after the oral administration of 75 mg. Peak amitriptyline plasma concentrations ranged from 10.8 to 43.7 ng/ml. The disappearance was biphasic and followed first-order kinetics. The mean elimination half-life was 36.1 hours.
Samuel H. Rosen +3 more
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