Results 201 to 210 of about 52,157 (302)

Plasma eMTBR‐tau243 as a disease biomarker across Alzheimer's disease clinical phenotypes

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION The concentration of endogenous tau microtubule‐binding region containing residue‐243 in plasma (eMTBR‐tau243) has been proposed to be a sensitive biomarker of tangle pathology in Alzheimer's disease (AD). We assessed eMTBR‐tau243 and phosphorylated tau217 (p‐tau217) with tau and Aβ‐positron emission tomography (PET) across ...
Jennifer L. Whitwell   +13 more
wiley   +1 more source

Exploring barriers and enablers of antibiotic amnesty campaigns. [PDF]

open access: yesJ Pharm Policy Pract
Howard P   +7 more
europepmc   +1 more source

Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We examined how amyloid beta (Aβ) and tau accumulation affected gray matter (GM) microstructural integrity and how such alterations impacted memory. METHODS We tested voxel‐wise mediation models to examine the relationships between (1) positron emission tomography‐derived Aβ and tau accumulation and GM microstructural integrity ...
Quentin Devignes   +9 more
wiley   +1 more source

Neuropathologic features of cognitively defined Alzheimer's disease subgroups in the Adult Changes in Thought study

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Individuals with Alzheimer's disease (AD) dementia can be subgrouped based on cognitive performance at diagnosis. We compared neuropathology across cognitively defined AD subgroups in the Adult Changes in Thought study. METHODS Scores for memory, executive functioning, language, and visuospatial abilities were derived from the ...
Caitlin S. Latimer   +12 more
wiley   +1 more source

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Mehri Salari   +3 more
wiley   +1 more source

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