Results 31 to 40 of about 55,848 (255)

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Amniotic and cervical fluids progranulin levels in pregnancies complicated by spontaneous preterm delivery with respect to intra-amniotic complications—a retrospective cohort study

Scientific Reports
The main aim of the study was to determine progranulin levels in amniotic and cervical fluid samples from pregnancies complicated by preterm prelabor rupture of membranes (PPROM) or preterm labor with intact membranes (PTL), with concomitant microbial ...
Ondrej Soucek, Marian Kacerovsky, Ivana Musilova, Rudolf Kukla, Radka Bolehovska, Pavel Bostik, Bo Jacobsson, Ctirad Andrys   +7 more
doaj   +1 more source

Development and Validation of a Rodent Model of Amniotic Fluid Exchange: A Prospective Laboratory-Based Study

Clinical and Experimental Obstetrics & Gynecology
Background: Significant interplay exists between the amniotic fluid and the developing fetus. However the true nature of the relationship between the amniotic fluid and the fetus, as well as the fetal membranes, is very poorly understood due to the lack ...
Braxton Forde, Samuel Martin, Jose L. Peiro   +2 more
doaj   +1 more source

High Mobility Group Box 1 in Pig Amniotic Membrane Experimentally Infected with E. coli O55

Biomolecules, 2021
Intra-amniotic infections (IAI) are one of the reasons for preterm birth. High mobility group box 1 (HMGB1) is a nuclear protein with various physiological functions, including tissue healing.
Igor Splichal, Alla Splichalova
doaj   +1 more source

A Novel Splice Variant in ERGIC1 Causes Arthrogryposis Multiplex Congenita—Characterization Using Urine‐Derived Cells

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis multiplex congenita (AMC) is defined as the presence of joint contractures affecting at least two body regions at birth. Three different ERGIC1 variants have been reported in individuals with AMC. Here, we report on a 16‐year‐old male with a homozygous ERGIC1 c.250+1G>A variant that was classified as a variant of uncertain ...
Lauren Kerr, Paul McKay, Juliana Marulanda, Zenghui Wu, Reggie Hamdy, Sena Tavukcu, Noémi Dahan‐Oliel, Frank Rauch   +7 more
wiley   +1 more source

Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor.

PLoS ONE, 2020
ObjectiveAmniotic fluid cytokines have been implicated in the mechanisms of preterm labor and birth. Cytokines can be packaged within or on the surface of extracellular vesicles.
Gaurav Bhatti, Roberto Romero, Gregory Edward Rice, Wendy Fitzgerald, Percy Pacora, Nardhy Gomez-Lopez, Mahendra Kavdia, Adi L Tarca, Leonid Margolis   +8 more
doaj   +1 more source

Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid

Environment International, 2022
Objective: To examine whether selected endocrine disrupting chemicals were present in pregnant women and passed through the placental barrier to amniotic fluid, potentially exposing the developing fetus.
Elvira V. Bräuner, Cecilie S. Uldbjerg, Youn-Hee Lim, Laura S. Gregersen, Marianna Krause, Hanne Frederiksen, Anna-Maria Andersson   +6 more
doaj   +1 more source

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

Clinical Significance of Echogenic Amniotic Fluid on Perinatal Outcome [PDF]

Al-Azhar International Medical Journal
Background: Amniotic fluid is the aqueous substance that envelops a developing fetus within the amniotic sac and often exhibits a transparent to light yellow hue.Objectives: To determine the characteristics of echogenic amniotic fluid, overcome needless ...
doaj   +1 more source

RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection

Journal of Innate Immunity, 2020
Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the mother and fetus as well as severe long-term neonatal morbidities.
Nardhy Gomez-Lopez, Roberto Romero, Aneesha Varrey, Yaozhu Leng, Derek Miller, Bogdan Done, Yi Xu, Gaurav Bhatti, Kenichiro Motomura, Meyer Gershater, Roger Pique-Regi, Adi L. Tarca   +11 more
doaj   +1 more source