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Medical Journal of Australia, 1977
A case of profound neutropenia and severe infection after the administration of amodiaquine is presented. The recommended dose for malaria prophylaxis was administered.
P, Gillespie, F, Wagner
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A case of profound neutropenia and severe infection after the administration of amodiaquine is presented. The recommended dose for malaria prophylaxis was administered.
P, Gillespie, F, Wagner
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Pharmacogenomics, 2008
Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Archives of Ophthalmology, 1982
A 34-year-old man ingested more then 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous ...
L W, Hirst +4 more
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A 34-year-old man ingested more then 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous ...
L W, Hirst +4 more
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Amodiaquine‐induced immune agranulocytosis
British Journal of Haematology, 1989SummaryThis report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment. The neutrophil counts returned to normal in one after stopping the drug while the other died of sepsis. Amodiaquine‐dependent circulating neutrophil IgG antibodies were demonstrated in both patients using the indirect granulocyte ...
B, Rouveix +4 more
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Amodiaquine-induced fulminant hepatitis
Journal of Hepatology, 1988Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria. Amodiaquine administration was continued for 44, 21 and 25 days after the onset of jaundice, respectively.
J, Bernuau +7 more
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Amodiaquine polymeric membrane electrode
Journal of Pharmaceutical and Biomedical Analysis, 2006The construction and electrochemical response characteristics of two types of poly(vinyl chloride) (PVC) membrane sensors for the determination of amodiaquine hydrochloride (ADQ.2HCl) are described. The sensing membrane comprised an ion-pair formed between the cationic drug and sodium tetraphenyl borate (NaTPB) or potassium tetrakis(4-chlorophenyl ...
Kimbeni Malongo, Trésor +5 more
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Pigmentation from amodiaquine simulating cyanosis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963Abstract A patient is described who on small weekly doses of amodiaquine hydrochloride developed wide-spread vivid blue pigmentation of the skin and buccal mucosa, so strikingly intense and diffuse that the initial clinical diagnosis was enterogenous cyanosis. Skin biopsy suggested the true nature of the condition.
J C, SHEE, P J, BARNARD
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