Results 261 to 270 of about 17,480 (292)

Immunogenicity of Amodiaquine in the Rat

International Archives of Allergy and Immunology, 1990
Amodiaquine is an antimalarial drug that has been associated with adverse reactions which may be immune mediated. Specific IgG anti-amodiaquine antibodies were detected after administration of the drug to rats (269 μmol/kg for 4 days), using an enzyme-linked immunosorbent assay employing amodiaquine conjugated to metallothionein as an antigen.
J.B. Clarke, B.K. Park, Neil R. Kitteringham, J.L. Maggs   +3 more
openaire   +3 more sources

Amodiaquine Pharmacogenetics

Pharmacogenomics, 2008
Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
openaire   +2 more sources

Amodiaquine – Induced Thrombocytopenia

Highland Medical Research Journal, 2005
We present a case of Amodiaquine induced severe thrombocytopenia in male 30 year old Nigerian accountant who has had previous episodes of bleeding diathesis associated with Amodiaquine ingestion. He was managed with prednisolone therapy and did not receive any blood or blood products since platelet concentrate was unavailable.
Chijioke A. Nwauche, OA Ejele
openaire   +2 more sources

Amodiaquine‐induced immune agranulocytosis

British Journal of Haematology, 1989
SummaryThis report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment. The neutrophil counts returned to normal in one after stopping the drug while the other died of sepsis. Amodiaquine‐dependent circulating neutrophil IgG antibodies were demonstrated in both patients using the indirect granulocyte ...
Laure Coulombel, J. P. Aymard, F. Chau, B. Rouveix, Laurent Abel   +4 more
openaire   +3 more sources

Green reversed-phase HPLC development strategy: Application to artesunate and amodiaquine analysis.

Journal of Separation Science, 2020
A green analytical chemistry strategy is described to develop a reversed phase HPLC method for amodiaquine and artesunate analysis using ethanol based mobile phases.
Moussa Yabré, L. Ferey, I. Somé, Olivier Mercier, K. Gaudin   +4 more
semanticscholar   +1 more source

[Safety and Efficacy of Artemether-Lumefantrine and Artesunate-Amodiaquine in Niger].

Bulletin de la Société de Pathologie Exotique, 2020
This study aims to evaluate the therapeutic efficacy and tolerance of two ACTs widely used for the treatment of uncomplicated malaria due to Plasmodium falciparum in Niger. The study was conducted from September to November 2017, at the Integrated Health
I. Ibrahima, I. Laminou, E. Adehossi, D. Maman, S. Boureima, H. Harouna, H. Hamidou, A. Mahamadou, I. Yacouba, J. Hadiza, I. A. Tidjani   +10 more
semanticscholar   +1 more source

Nearly Fatal Reaction to Amodiaquine

JAMA, 1962
With the expanded use of antimalarial drugs based upon their effectiveness as anti-inflammatory agents, an increase in the number of adverse reactions to these agents was to be expected. This report describes the development of hepatitis and agranulocytosis in a patient who received amodiaquine, one of the newer antimalarials, and emphasizes the ...
Lloyd G. Bartholomew, David G. Hanlon, Harold O. Perry   +2 more
openaire   +3 more sources

Amodiaquine-induced fulminant hepatitis

Journal of Hepatology, 1988
Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria. Amodiaquine administration was continued for 44, 21 and 25 days after the onset of jaundice, respectively.
Bernard Rueff, Dominique Larrey, Claude Degott, F. Verdier, Bernard Campillo, Jacques Bernuau, Jean-Pierre Benhamou, Dominique Pessayre   +7 more
openaire   +3 more sources

Pigmentation from amodiaquine simulating cyanosis

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963
Abstract A patient is described who on small weekly doses of amodiaquine hydrochloride developed wide-spread vivid blue pigmentation of the skin and buccal mucosa, so strikingly intense and diffuse that the initial clinical diagnosis was enterogenous cyanosis. Skin biopsy suggested the true nature of the condition.
J. Charles Shee, P.J. Barnard
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Amodiaquine polymeric membrane electrode

Journal of Pharmaceutical and Biomedical Analysis, 2006
The construction and electrochemical response characteristics of two types of poly(vinyl chloride) (PVC) membrane sensors for the determination of amodiaquine hydrochloride (ADQ.2HCl) are described. The sensing membrane comprised an ion-pair formed between the cationic drug and sodium tetraphenyl borate (NaTPB) or potassium tetrakis(4-chlorophenyl ...
Kimbeni Malongo, Trésor, Blankert, Bertrand, Kambu, O., Amighi, Karim, Nsangu, J., Kauffmann, Jean-Michel   +5 more
openaire   +3 more sources