Results 261 to 270 of about 17,783 (291)
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Pharmacogenomics, 2008
Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Amodiaquine – Induced Thrombocytopenia
Highland Medical Research Journal, 2005We present a case of Amodiaquine induced severe thrombocytopenia in male 30 year old Nigerian accountant who has had previous episodes of bleeding diathesis associated with Amodiaquine ingestion. He was managed with prednisolone therapy and did not receive any blood or blood products since platelet concentrate was unavailable.
Chijioke A. Nwauche, OA Ejele
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Nearly Fatal Reaction to Amodiaquine
JAMA, 1962With the expanded use of antimalarial drugs based upon their effectiveness as anti-inflammatory agents, an increase in the number of adverse reactions to these agents was to be expected. This report describes the development of hepatitis and agranulocytosis in a patient who received amodiaquine, one of the newer antimalarials, and emphasizes the ...
Lloyd G. Bartholomew +2 more
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Green reversed-phase HPLC development strategy: Application to artesunate and amodiaquine analysis.
Journal of Separation Science, 2020A green analytical chemistry strategy is described to develop a reversed phase HPLC method for amodiaquine and artesunate analysis using ethanol based mobile phases.
Moussa Yabré +4 more
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Amodiaquine‐induced immune agranulocytosis
British Journal of Haematology, 1989SummaryThis report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment. The neutrophil counts returned to normal in one after stopping the drug while the other died of sepsis. Amodiaquine‐dependent circulating neutrophil IgG antibodies were demonstrated in both patients using the indirect granulocyte ...
Laure Coulombel +4 more
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Amodiaquine-induced fulminant hepatitis
Journal of Hepatology, 1988Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria. Amodiaquine administration was continued for 44, 21 and 25 days after the onset of jaundice, respectively.
Bernard Rueff +7 more
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Pigmentation from amodiaquine simulating cyanosis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963Abstract A patient is described who on small weekly doses of amodiaquine hydrochloride developed wide-spread vivid blue pigmentation of the skin and buccal mucosa, so strikingly intense and diffuse that the initial clinical diagnosis was enterogenous cyanosis. Skin biopsy suggested the true nature of the condition.
J. Charles Shee, P.J. Barnard
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Amodiaquine polymeric membrane electrode
Journal of Pharmaceutical and Biomedical Analysis, 2006The construction and electrochemical response characteristics of two types of poly(vinyl chloride) (PVC) membrane sensors for the determination of amodiaquine hydrochloride (ADQ.2HCl) are described. The sensing membrane comprised an ion-pair formed between the cationic drug and sodium tetraphenyl borate (NaTPB) or potassium tetrakis(4-chlorophenyl ...
Kimbeni Malongo, Trésor +5 more
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Acta Tropica, 2009
The effects of amodiaquine, artesunate and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia (PfMAA) and the recovery from PfMAA were evaluated in 328 children with uncomplicated malaria randomized to the standard dose regimens of the three drug treatments.
S T Balogun +3 more
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The effects of amodiaquine, artesunate and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia (PfMAA) and the recovery from PfMAA were evaluated in 328 children with uncomplicated malaria randomized to the standard dose regimens of the three drug treatments.
S T Balogun +3 more
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EFFECTS OF AMODIAQUIN AND QUINIDINE ON CARDIAC CONDUCTION
Canadian Journal of Physiology and Pharmacology, 1965The effects of the antiarrhythmia agents amodiaquin and quinidine on conduction times through the atrium and the specialized conducting tissue to the ventricular myocardium have been determined from records obtained with needle electrodes suitably placed in isolated blood perfused dog hearts.
Bryan W. Kirk, Peter E. Dresel
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