Results 41 to 50 of about 73,538 (326)

Distribution of relaxation times as a tool to monitor tissue electroporation

Scientific Reports
In this paper, the effect of electroporation on tissue is studied using the concept of distribution of relaxation times (DRT). DRT is an alternative to traditional electrical impedance spectroscopy, where measurement data are analyzed on a time scale ...
Théo Le Berre, Damien Voyer, Guilhem Rival, Marie Frénéa-Robin, Julien Marchalot   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Sobre os efeitos das correntes elétricas (segunda parte)

Revista Brasileira de História da Ciência, 2009
Apresentamos a tradução comentada da segunda parte da primeira obra de A. M. Ampère sobre os fenômenos eletrodinâmicos. Nesse artigo Ampère descreve suas observações da ação entre correntes elétricas e suas consequências qualitativas.
João Paulo M. de C. Chaib, André K. T. Assis   +1 more
doaj   +1 more source

Safety hazards associated with the charging of lithium/sulfur dioxide cells [PDF]

, 1986
A continuing research program to assess the responses of spirally wound, lithium/sulfur dioxide cells to charging as functions of charging current, temperature, and cell condition prior to charging is described.
Barnes, J. A., Bis, R. F., Frank, H., Halpert, G., Lawson, D. D.   +4 more
core   +1 more source

Iterative methods for k-Hessian equations

, 2018
On a domain of the n-dimensional Euclidean space, and for an integer k=1,...,n, the k-Hessian equations are fully nonlinear elliptic equations for k >1 and consist of the Poisson equation for k=1 and the Monge-Ampere equation for k=n.
Awanou, Gerard
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

André-Marie Ampère. The chemical side

Educación Química, 2018
El nombre André-Marie Ampère (1775-1836) trae inmediatamente a la memoria los conceptos de corriente eléctrica y magnetismo. Es cierto que éstas fueron, de lejos, las más importantes contribuciones científicas de Ampère, pero él también nos dejó ideas ...
Jaime Wisniak
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source