Results 51 to 60 of about 70,537 (277)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

The Monge-Ampere equation: various forms and numerical methods

, 2010
We present three novel forms of the Monge-Ampere equation, which is used, e.g., in image processing and in reconstruction of mass transportation in the primordial Universe.
Ampère, Axelsson, Bakelman, Benamou, Brenier, Brenier, Dean, Dean, Dean, Delzanno, Finn, Frisch, Gilbarg, Glimm, Gutiérrez, Haker, Hurtut, Kostrikin, Loeper, Mohayaee, Moutarde, O. Podvigina, Oliker, Peebles, Podvigina, U. Frisch, V. Zheligovsky, Zel’dovich   +27 more
core   +3 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Introducing Joint Research Project «Quantum Ampere» for the realisation of the new SI ampere

EPJ Web of Conferences, 2014
The metrology community lately has adopted the long-term aim of basing the SI unit system on fundamental constants of nature. The base electrical unit, the ampere, will then be re-defined in terms of a fixed value of the elementary charge e.
Scherer Hansjörg, Giblin Stephen P., Jehl Xavier, Manninen Antti, Piquemal François, Ritchie David A.   +5 more
doaj   +1 more source

Practical quantum realization of the ampere from the electron charge

, 2016
One major change of the future revision of the International System of Units (SI) is a new definition of the ampere based on the elementary charge \emph{e}.
Brun-Picard, J., Djordjevic, S., Leprat, D., Poirier, W., Schopfer, F.   +4 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Absorpsi dan Responsivitas Larutan Porphyrin Alam Hasil Isolasi dari Spirulina sebagai Bahan Material Photonics

Jurnal Fisika Flux, 2017
Telah dilakukan pengujian karakteristik absorpsi larutan porphyrin dan responsivitas cahaya. Larutan senyawa molekul porphyrin diisolasi dari mikroalgae spirulina.
Agus Supriyanto, Kusumandari Kusumandari, Fahru Nurosyid, Antik Erlina   +3 more
doaj   +3 more sources

Vibrating-membrane electrometer has high conversion gain [PDF]

, 1965
Vibrating-membrane transducer in a circuit can measure current below 10 to-the-minus 17 ampere.
Coon, G. W., Dimeff, J.
core   +1 more source