Results 71 to 80 of about 73,538 (326)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Pocket nickel cadmium cell and battery evaluation [PDF]

open access: yes
The Nickel Cadmium 129-ampere hour cell was tested in order to characterize the cell under controlled conditions. Results of charge characterization and discharge characterization are reported.
Lear, J. W.
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

The properties of metal contacts on TiO2 thin films produced by reactive magnetron sputtering [PDF]

open access: yesТехнологія та конструювання в електронній апаратурі, 2010
The article deals with research on volt-ampere characteristics of metal contacts (Al, Cr, In, Mo, Ti) on titanium dioxide thin films and influence of annealing in vacuum on their electric properties. Volt-ampere characteristics measurements were taken by
В. В. Брус   +4 more
doaj   +1 more source

Auxiliary Pulse Tripling Circuit with Low kVA Rating to Reduce Input Current Harmonic Distortion in 12 Pulse Rectifier [PDF]

open access: yesInternational Journal of Industrial Electronics, Control and Optimization
In recent years, to increase the number of pulses in 12-pulse autotransformer rectifiers (12-PARs) and reduce the input current total harmonic distortion (IC-THD), without increasing the cost and complexity, the technique of pulse multiplication circuit ...
Rohollah Abdollahi   +1 more
doaj   +1 more source

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara   +18 more
wiley   +1 more source

Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment

open access: yesArthritis Care &Research, EarlyView.
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Andrea Fava   +48 more
wiley   +1 more source

Some applications and maximum principles for multi-term time-space fractional parabolic Monge-Ampère equation

open access: yesDemonstratio Mathematica
This study first establishes several maximum and minimum principles involving the nonlocal Monge-Ampère operator and the multi-term time-space fractional Caputo-Fabrizio derivative.
Guan Tingting, Wang Guotao, Araci Serkan
doaj   +1 more source

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