Results 101 to 110 of about 123,317 (298)

Role of the mesoamygdaloid dopamine projection in emotional learning [PDF]

, 2010
Amygdala dopamine is crucially involved in the acquisition of Pavlovian associations, as measured via conditioned approach to the location of the unconditioned stimulus (US).
AA Grace, AM Murray, AR Wagner, AR Wagner, AR Wagner, BJ Everitt, BJ Everitt, CJ Harmer, CJ Harmer, CW Mueller, DA Powell, E Asan, Emily Salussolia, ES Parker, Gavin D. Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GE Müller, GJ Mogenson, JA Parkinson, JA Parkinson, JA Rosenkranz, JA Rosenkranz, JL McGaugh, JR Taylor, JV Hinrichs, KA Burke, LJ Freedman, M Fleshler, M McDannald, M Mintz, M Zoli, MT Bardo, NM White, P Blundell, P Blundell, P Holland, P Sokoloff, Paul K. Hitchcott, PJ Lang, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, Q Greba, RA Wise, RC Lennartz, RJ Scibilia, RM Colwill, SB Ostlund, SR Jones, TE Robinson, TE Robinson, TW Robbins, W Schultz   +60 more
core   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism

Scientific Reports, 2017
Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance.
Karly M. Turner, James Peak, Thomas H. J. Burne   +2 more
doaj   +1 more source

Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.

PLoS ONE, 2013
The development of amphetamine dependence largely depends on the effects of amphetamine in the brain reward systems. Ghrelin, an orexigenic peptide, activates the reward systems and is required for reward induced by alcohol, nicotine, cocaine and ...
Petra Suchankova, Elisabet Jerlhag, Nitya Jayaram-Lindström, Staffan Nilsson, Kjell Toren, Annika Rosengren, Jörgen A Engel, Johan Franck   +7 more
doaj   +1 more source

Female rat hippocampal cell density after conditioned place preference [PDF]

, 2014
The hippocampus is important for learning tasks, such as conditioned place preference (CPP), which is widely used as a model for studying the reinforcing effects of drugs with dependence liability.
Babakordi, F., Jahanshahi, M., Nikmahzar, E.G., Shabani, R.   +3 more
core  

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Amphetamine Abuse Related Acute Myocardial Infarction

Case Reports in Cardiology, 2016
Amphetamine abuse is a global problem. The cardiotoxic manifestations like acute myocardial infarction (AMI), heart failure, or arrhythmia related to misuse of amphetamine and its synthetic derivatives have been documented but are rather rare ...
Archana Sinha, O’Dene Lewis, Rajan Kumar, Sri Lakshmi Hyndavi Yeruva, Bryan H. Curry   +4 more
doaj   +1 more source

Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning [PDF]

, 2014
When psychostimulant drugs like amphetamine are administered repeatedly in the presence of a contextual stimulus complex, long-lasting associations form between the unconditioned effects of the drug and the contextual stimuli.
B.F. Singer, Banasikowski, Benavides, Bibb, Britt, Buraei, Cervo, Cruz, Fischer, Fischer, Gipson, Hawasli, J. Forneris, Leyton, Leyton, Li, Moses, P. Vezina, Pierce, Price, Robinson, Singer, Stewart, Taylor, Vezina, Vezina, Vezina, Xin   +27 more
core   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Dysfunctional play and dopamine physiology in the Fischer 344 rat

, 2011
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain.
Akopian, Akopian, Akopian, Alcaro, Alessandri, Almeida, Baldwin, Bamford, Basar, Beatty, Beatty, Bell, Berridge, Breier, Broderick, Burgdorf, Burgdorf, Burghardt, Burghardt, Burghardt, Cadoni, Cadoni, Calabresi, Chambers, Cheng, Cordier, Crawford, Crawley, Cynthia A. Crawford, Davis, Depoortere, Fagen, Feifel, Field, Fleckenstein, Gainetdinov, Garnik Akopian, Garris, Geyer, Glowa, Gomez-Serrano, Gonon, Gordon, Guitart, Gulley, Guo, Gurden, Hariri, Harris, Helmeste, Huang, Huang, Hubbard, Humphries, Ikemoto, John P. Walsh, Kerr, Knutson, Kolomiets, Kosten, Leblois, Leipold, McGraw La, Meaney, Miles, Niesink, Panksepp, Panksepp, Panksepp, Panksepp, Panksepp, Patel, Patel, Pellegrini, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Petzinger, Pliszka, Reif, Robinson, Romeo, Sagvolden, Schulte, Sills, Siviy, Siviy, Siviy, Siviy, Siviy, Siviy, Skuse, Smith, Smith, Spear, Spinka, Stamford, Stephen M. Siviy, Stohr, Sulzer, Surmeier, Swerdlow, Swerdlow, Swerdlow, Tang, Terranova, Trezza, Trezza, Trezza, Trezza, Tripp, Van den Berg, Vanderschuren, Vanderschuren, Vanderschuren, Varty, Villar, Volkow, Voorn, Walker, Young   +126 more
core   +1 more source