Results 81 to 90 of about 107,290 (304)

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node-Targeting and Augments mRNA Vaccine Efficacy. [PDF]

Adv Sci (Weinh)
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Ha M, Kim J, Kim S, Naidu GS, Cho S, Yong SB.   +5 more
europepmc   +2 more sources

Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation

, 2021
© 2021 American Chemical Society. Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate ...
Buchwald, Stephen L, Dhanjee, Heemal H, Rodriguez, Jacob, Jacob Rodriguez, Stephen L. Buchwald, Heemal H. Dhanjee   +5 more
core   +1 more source

In Situ Interfacial Assembly of Dynamic Semi‐Interpenetrating Biopolymer Networks for Robust and Mechanically Adaptive Droplet Interfaces

Advanced Functional Materials, EarlyView.
A dynamic interfacial semi‐interpenetrating polymer network is constructed by sequential assembly of β‐sheet‐rich SF and CS‐RL. The SF framework provides mechanical strength, while dynamically associated CS‐RL enables local rearrangement, allowing droplets to rapidly reconfigure without loss of interfacial integrity.
Yaping Zhang, Yujie Liu, Yikai Xu, Xunda Feng, Ling Zhang, Hongbo Zeng, Hao Liu, Xiaohui Mao   +7 more
wiley   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Amphiphilic galactosylated phthalocyanines

Journal of Porphyrins and Phthalocyanines, 2008
Two amphiphilic Ni phthalocyanines bearing a hydrophilic galactose head facing six hydrophobic thiohexyl chains are described. The place of the glycosylation step on the overall synthetic pathway is discussed. For the first time, phthalocyanines are used as acceptors in glycosylation reactions, in excellent yields.
Kumru, Ufuk, Ermeydan, Mahmut Ali, Dumoulin, Fabienne, Ahsen, Vefa   +3 more
openaire   +2 more sources

Microfluidic Architecting of Patchy MXene Core‐Shell Particles for Ultralow‐Loading Photothermal Shape‐Memory Actuation

Advanced Functional Materials, EarlyView.
Spatially distributing Ti3C2Tx nanosheets into core‐shell architecture, rather than as directly dispersed flakes, mitigates aggregation and enhances photon harvesting. When the Ti3C2Tx core‐shell particles are incorporated into a shape‐memory polymer matrix at an ultralow loading of 0.0024 wt%, the improved photothermal conversion translates into ...
May Maung Zaw, Maxim M. Trubyanov, Qian Wang, Siyu Chen, Hongyi Chen, Keyu Chen, Hongbin Sun, Muthu Vignesh Vellayappan, Xiaoying Qi, Sharon Mui Ling Nai, Kostya S. Novoselov, David W. Rosen, Daria V. Andreeva   +12 more
wiley   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Weakly Coordinating Amphiphilic Organoborate Block Copolymers

, 2016
Weakly Coordinating Amphiphilic Organoborate Block ...
Edward M. Bonder (1526413), Frieder Jäkle (1422781), Chengzhong Cui (1852180)   +2 more
core   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self-Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior. [PDF]

Angew Chem Int Ed Engl
DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base‐pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first‐formed interactions biasing the final morphology: short hydrophobic chain strands form DX‐tiles and then into stars, while long‐chain strands form SNAs and ...
Wu Y, Rafique MG, Saab C, Sleiman H.
europepmc   +2 more sources