Results 241 to 250 of about 95,889 (290)

Treatment‐Refractory Tracheobronchitis in Crohn's Disease: A Rare Pulmonary Manifestation of Inflammatory Bowel Disease

Respirology Case Reports, Volume 13, Issue 10, October 2025.
In this report, we present a case of tracheobronchitis in Crohn's disease presenting with a chronic productive cough while on infliximab. The diagnosis was made on bronchoscopy, which revealed inflammation of the trachea and main bronchi, with biopsies demonstrating squamous cell metaplasia consistent with pulmonary inflammatory bowel disease ...
Gabriel Gurieff, Senthuran Shivakumar, Joy Lee, Finlay Macrae, Tracy L. Leong   +4 more
wiley   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
wiley   +1 more source

A real-world study based on the FAERS database evaluating adverse drug reactions in three amphotericin B lipid formulations. [PDF]

J Pharm Policy Pract
Tong B, Wang J, Zhang Y, Liu Y, Wang J, Duan L, Yan Y, Sun Q, Luan Y, Yu J, Zhou C.   +10 more
europepmc   +1 more source

Review of experimental equine synovitis models for inducing lameness

Equine Veterinary Education, Volume 37, Issue 10, Page 547-560, October 2025.
Summary Lameness in horses, particularly in relation to osteoarthritis (OA), is complex and variable, highlighting the importance of experimental models in advancing our understanding of pain and lameness. Synovitis plays a critical role in the development of OA, and reversible models of synovitis offer valuable insights into physiology and potential ...
A. Dockery, B. Beasley, V. J. Moorman
wiley   +1 more source

Thermal ablation combined with percutaneous injection of amphotericin B for the treatment of chronic pulmonary aspergillosis: a case series. [PDF]

Front Med (Lausanne)
Liu X, Nan F, An P, Deng K, Li L, Wang H.   +5 more
europepmc   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Protein-mediated stabilization of amphotericin B increases its efficacy against diverse fungal pathogens. [PDF]

Microbiol Spectr
Fernandes KE, Johnston CL, Williams BC, Carter DA, Sunde M.   +4 more
europepmc   +1 more source

Activation of G protein‐coupled parathyroid hormone receptors in rat incisor odontoblasts promotes mineralization via cyclic adenosine monophosphate, not Ca2+ signalling: In vitro study

International Endodontic Journal, Volume 58, Issue 10, Page 1616-1628, October 2025.
Abstract Aim Parathyroid hormone (PTH) and its Gαs‐coupled receptors, PTH receptor, mediate odontoblast differentiation; however, the detailed intracellular adenylyl cyclase‐mediated signalling pathway mediated by the PTH–PTH receptor axis remains to be elucidated. Therefore, we measured the intracellular levels of cyclic adenosine monophosphate (cAMP)
Natsuki Saito, Takehito Ouchi, Maki Kimura, Ryuya Kurashima, Yoshiyuki Shibukawa   +4 more
wiley   +1 more source

Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions. [PDF]

PLoS Negl Trop Dis
Anuntasomboon P, Siripattanapipong S, Unajak S, Choowongkomon K, Burchmore R, Leelayoova S, Mungthin M, E-Kobon T.   +7 more
europepmc   +1 more source

UV‐A Radiation Impairs Sebaceous‐Gland‐Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum‐Like Lipid Composition

Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.
ABSTRACT Background Sebaceous glands (SGs) secrete sebum to form a protective barrier that maintains skin health. However, exposure to ultraviolet A (UV‐A) radiation damages the skin barrier, leading to dryness and inflammation. Aims In this study, we investigated how UV‐A radiation alters SG function, focusing on inflammation and changes in the ...
Wangyue Dong, Maori Kono, Masayuki Takaishi, Ayumi Kyuka, Hiroko Kato, Fumitaka Fujita   +5 more
wiley   +1 more source