Results 141 to 150 of about 1,079,858 (266)

Development and application of a TaqMan probe-based pentaplex qPCR for the rapid detection and differential identification of five pathogens. [PDF]

Front Microbiol
Gao ZQ, Fu R, Xing J, Yao SS.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer. [PDF]

NPJ Precis Oncol
Kim D, Chung H, Abed M, Ma J, Molden N, Shim C, Rajendran D, Yen J, Jeong J, Levy A, Yaniz-Galende E, Blanc-Durand F, Desauw C, Follana P, Bonichon-Lamichhane N, Oudard S, D'Hondt V, Gavoille C, Jandial DD, Meric-Bernstam F, Liu JF, Simpkins F, Randall LM, Leary A, Lackner MR, Harismendy O.   +25 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Correction to "The Variant Senescence-Associated Secretory Phenotype Induced by Centrosome Amplification Constitutes a Pathway That Activates Hypoxia-Inducible Factor-1α". [PDF]

Aging Cell
europepmc   +1 more source

Recent advances in isothermal amplification techniques for detection of animal diseases. [PDF]

Front Vet Sci
Tooryan F, Enyertornye B, Choudhury FJ, Velayudhan BT.   +3 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

A novel approach to hearing amplification: audiometric outcomes from Nuance Audio over-the-counter hearing aid glasses. [PDF]

Acta Otorhinolaryngol Ital
Albera A, Boldreghini M, Girotto L, Albera R, Cassandro C, Canale A.   +5 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Establishment and application of a quadruple target real-time PCR assay for detecting Yersinia pestis. [PDF]

PLoS One
Wang W, Zhang X, Yu H, Wang Z.
europepmc   +1 more source