Results 191 to 200 of about 919,177 (398)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Nonlinearity- and Dispersion-Controlled High-Energy All-Fiber Femtosecond Laser System with Peak Power Exceeding 0.5 GW. [PDF]

Nanomaterials (Basel)
Li F, Li Q, Xing J, Cao X, Wen W, Wang L, Wei Y, Zhao H, Wang Y, Fu Y, Zhao W.   +10 more
europepmc   +1 more source

All-optical logic gates using semiconductor optical amplifier assisted by optical filter

, 2005
Z. Li, Y. Liu, S. Zhang, Heongkyu Ju, H. de Waardt, G.D. Khoe, H.J.S. Dorren, D. Lenstra   +7 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Design of Dual Continuous-Mode Class-J Power Amplifiers with Harmonic Matching Networks for X and Ku Bands. [PDF]

Micromachines (Basel)
Yuan Y, Zhao X, Fan J, Yu Z.
europepmc   +1 more source

Advances in Phase Sensitive Amplifiers Based on PPLN Waveguides for Optical Communication [PDF]

, 2016
Takeshi Umeki, O. Tadanaga, Takushi Kazama, Koji Enbutsu, Yutaka Miyamoto, Hirokazu Takenouchi   +5 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Light-insensitive organic solar-powered amplifiers. [PDF]

Nat Commun
Wu Q, Wang S, Gao W, Chen Z, Tao J, Song X, Yan S, Zhu H, Zhou K, Jiang L, Xu X, Jen AK, Ma W.   +12 more
europepmc   +1 more source

METHOD OF COMPLEX REFLECTION PARAMETERS MEASUREMENT OF TRANSISTOR LOADS USING A SIMULATOR-ANALYZER OF MICROWAVE AMPLIFIERS AND OSCILLATORS

, 2021
Sergei V. Savelkaev, Nadezhda A. Vikhareva, Natalia V. Chekotun   +2 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source