Results 151 to 160 of about 5,873 (226)

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

CANRIG: Cross‐Attention Neural Face Rigging with Variable Local Control

Computer Graphics Forum, EarlyView.
Abstract Facial animation is one of the most labor‐intensive aspects of animation and VFX, as traditional rigging consumes weeks of expert time and forces animators to spend countless hours manipulating hundreds of controls to achieve varied expressions.
Arad Mohammadi, Sebastian Weiss, Jakob Buhmann, Loic Ciccone, Robert W. Sumner, Derek Bradley, Martin Guay   +6 more
wiley   +1 more source

Comparative species distribution model framework for marine conservation and its application to loggerhead turtles in the Mediterranean

Conservation Biology, EarlyView.
Abstract Modeling species distributions in dynamic pelagic environments remains challenging, particularly for wide‐ranging and highly mobile species when there is limited guidance on model performance. This limitation constrains the effective use of species distribution models (SDMs) in marine conservation, where robust and transferable predictions are
E. Pasanisi, F. Maffucci, F. Atzori, M. Azzolin, I. Campana, L. Carosso, A. Castelli, M. Costantino, R. Crosti, L. David, N. Di‐Meglio, M. Farina, N. Fraija‐Fernández, O. Garcia‐Garin, M. Gazo, M. Gregorietti, F. Grossi, S. Hochscheid, R. Míguez‐Lozano, A. Moulins, D. S. Pace, M. Pecoraro, E. Pignata, J. A. Raga, M. Roul, E. Santini, G. Sarà, A. Scuderi, R. Teti, P. Tepsich, M. Vitale, M. Vighi, A. Arcangeli   +32 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Inflammation, Endothelial Dysfunction, and Platelet Dysregulation in Atrial Fibrillation with Chronic Kidney Disease: Toward a Biology-Informed Anticoagulation Strategy. [PDF]

Life (Basel)
Tanasescu MD, Rosu AM, Minca A, Grigorie MM, Timofte D, Ionescu D.   +5 more
europepmc   +1 more source

Understanding organizational–professional conflict: The effects of organizational controls and professional field strength

European Management Review, EarlyView.
Abstract Organizational–professional conflict (OPC) occurs when organizations encourage professionals such as doctors, accountants, and lawyers to behave in ways that are not consistent with their professional norms. This may lead to unethical behavior, while it also reduces job satisfaction and increases turnover intentions.
Sander van Triest, Helena Kloosterman, Christopher Williams   +2 more
wiley   +1 more source

Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders. [PDF]

Channels (Austin)
Li B, Dong Y, Chen Y, Liu C, Li Y.
europepmc   +1 more source

Chief Executive Officers and ESG: A Bibliometric and Systematic Literature Review and Research Agenda

European Financial Management, EarlyView.
ABSTRACT This work explores the historical, current, and future direction of the research on the relationship between CEO characteristics and ESG commitment, including ESG controversies—a recent key measure of corporate sustainability reputation that remains underexplored.
Paolo Agnese, Francesca Romana Arduino, Andrea Delle Foglie, Giovanni Ferri   +3 more
wiley   +1 more source

Beyond the Left Atrium: Genetic and Renal Determinants of Atrial Fibrillation in Hypertrophic Cardiomyopathy. [PDF]

Korean Circ J
Jung MH.
europepmc   +1 more source