Results 71 to 80 of about 173,727,387 (260)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies

Frontiers in Psychiatry
Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, and bipolar disorder.
Giuseppe Pierpaolo Merola, Livio Tarchi, Luigi F. Saccaro, Farnaz Delavari, Farnaz Delavari, Camille Piguet, Camille Piguet, Dimitri Van De Ville, Dimitri Van De Ville, Giovanni Castellini, Valdo Ricca   +10 more
doaj   +1 more source

Low-frequency fluctuations in semiconductor ring lasers with optical feedback

, 2015
In this paper, we experimentally and numerically study the dynamics of semiconductor ring lasers that are subjected to long delay and moderate self-feedback.
Van der Sande, Guy, Nguimdo, Romain Modeste, Mashal, L., Soriano, Miguel C.   +3 more
core   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Connections relevant for low frequency oscillations.

, 2016
The matrix elements show the sensitivity of the peak amplitude of low frequency fluctuations on the individual connections. Same display as in Fig 5C.
Hannah Bos (3220512), Markus Diesmann (221260), Moritz Helias (306448)   +2 more
core   +1 more source

Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients

Scientific Reports
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from insulin secretion and/or resistance. This study investigated intrinsic brain activity alterations using static and dynamic resting-state fMRI ...
Yongsheng Liang, Weiyin Vivian Liu, Mingrui Li, Qingzhi Feng, Shouchao Wei, Wenjia Yang, Zihua Guan, Jie Li, Wei Wei, Meilian Li, Hailing Zhou   +10 more
doaj   +1 more source

Low-frequency fluctuations in a semiconductor laser with phase conjugate feedback [PDF]

, 2001
We analyze the dynamics of a semiconductor laser with phase conjugate optical feedback, using numerical simulations based on rate equations for the complex amplitude of the electric field and the carrier density.
McInerney, John G., Huyet, Guillaume, O'Brien, D   +2 more
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Low frequency temperature fluctuations in the upper 400 meters of the Central North Pacific [PDF]

, 1980
We investigate the low frequency temperature fluctuations, with time scales of months to years, in the upper 400 m of the Central North Pacific by analyzing the TRANSPAC temperature data collected as a part of the North Pacific Experiment and the ...
Kang, Yong Quin
core   +1 more source