Results 131 to 140 of about 16,501 (255)

Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
ADAM19 is identified as a novel target for senescent chondrocyte rejuvenation. Knockdown of ADAM19 results in the attenuation of cellular senescence and the formation of proliferative extracellular matrix‐synthesizing chondrocytes. senHMSN_si‐ADAM19 can target deliver therapeutic siRNA into senescent cells and rejuvenate hyaline cartilage in ...
Jiasheng Wang   +6 more
wiley   +1 more source

Electrocutions in Free‐Ranging Platyrrhine Nonhuman Primates: Diagnostic Features for a Threatening Condition

open access: yesAmerican Journal of Primatology, Volume 87, Issue 4, April 2025.
Epidemiological and pathological features of electrocutions in free‐ranging new‐world monkeys. ABSTRACT Electrical accidents pose a considerable threat to wildlife in anthropized regions, particularly arboreal mammals, as evidenced by cases of electrocutions in nonhuman primates (NHPs). This study characterized the frequency, anatomic distribution, and
Rafaela M. Barros   +8 more
wiley   +1 more source

A LEAP Forward in Wildlife Conservation: A Standardized Framework to Determine Mortality Causes in Large GPS‐Tagged Birds

open access: yesEcology and Evolution, Volume 15, Issue 4, April 2025.
A novel framework for determining the causes of mortality of large GPS‐tagged birds, the LIFE EUROKITE Assessment Protocol (LEAP), was developed. LEAP integrates GPS tracking data, site investigation, and necropsy to derive mortality causes and a corresponding certainty score. Two case studies demonstrated improvements in mortality assessments compared
Connor T. Panter   +87 more
wiley   +1 more source

Interleukin‐8/Matrix Metalloproteinase‐9 Axis Impairs Wound Healing in Type 2 Diabetes through Neutrophil Extracellular Traps‐Fibroblast Crosstalk

open access: yesEuropean Journal of Immunology, Volume 55, Issue 4, April 2025.
Neutrophil extracellular traps (NETs) in type 2 diabetes induce a pro‐fibrotic but functionally impaired phenotype in cutaneous fibroblasts, associated with collagen breakdown by NET‐bound MMP‐9. IL‐8 released in NETs promotes its own expression in both neutrophils/fibroblasts and neutrophil MMP‐9 production, creating positive feedback loops that ...
Dimitrios Tsilingiris   +15 more
wiley   +1 more source

Induced Pseudomembrane Enrichment in Long Nerve Allograft Reconstruction

open access: yesMuscle &Nerve, Volume 71, Issue 4, Page 662-669, April 2025.
ABSTRACT Introduction/Aims Long nerve defects are typically reconstructed with autograft or processed acellular nerve allograft (PNA). PNA is convenient and avoids donor morbidity but lacks the neurotrophic environment of autograft. Increased levels of neurotrophic factors have been identified in pseudomembranes induced around silicone implanted ...
Omar A. Protzuk   +5 more
wiley   +1 more source

The effects of microprocessor prosthetic knee use in early rehabilitation: A pilot randomized controlled trial

open access: yesPM&R, Volume 17, Issue 4, Page 371-383, April 2025.
Abstract Background Microprocessor‐controlled prosthetic knees (MPKs) improve safety, stability, and mobility for people with transfemoral amputation. Despite these benefits, MPKs are often not used for people in early rehabilitation. Objective To assess the feasibility of a study that compares MPKs and nonmicroprocessor knees (NMPKs) for people with ...
Sara J. Morgan   +5 more
wiley   +1 more source

Lactate Levels in a Replanted Limb as an Early Biomarker for Assessing Post-Surgical Evolution: A Case Report. [PDF]

open access: yesDiagnostics (Basel)
Belu A   +9 more
europepmc   +1 more source

A T2 Translational Science Modified Delphi Study: The Ethical Triage and Treatment of Entrapped and Mangled Extremities in Resource‐Scarce Environments

open access: yesWorld Journal of Surgery, Volume 49, Issue 4, Page 1051-1060, April 2025.
ABSTRACT Background There is a lack of ethical triage and treatment guidelines for the entrapped and mangled extremity (E&ME) in resource‐scarce environments (RSE): mass casualty incidents, low‐ to middle‐income countries, complex humanitarian emergencies including conflict, and prolonged transport times (RSE).
Eric S. Weinstein   +11 more
wiley   +1 more source

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