Results 131 to 140 of about 16,501 (255)
Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
Advanced Science, Volume 12, Issue 13, April 3, 2025.ADAM19 is identified as a novel target for senescent chondrocyte rejuvenation. Knockdown of ADAM19 results in the attenuation of cellular senescence and the formation of proliferative extracellular matrix‐synthesizing chondrocytes. senHMSN_si‐ADAM19 can target deliver therapeutic siRNA into senescent cells and rejuvenate hyaline cartilage in ...Jiasheng Wang, Peng Guo, Dongmei Wu, Junzhi Yi, Qi Jiang, Jiajie Hu, Hongwei Ouyang +6 morewiley +1 more sourceElectrocutions in Free‐Ranging Platyrrhine Nonhuman Primates: Diagnostic Features for a Threatening Condition
American Journal of Primatology, Volume 87, Issue 4, April 2025.Epidemiological and pathological features of electrocutions in free‐ranging new‐world monkeys. ABSTRACT
Electrical accidents pose a considerable threat to wildlife in anthropized regions, particularly arboreal mammals, as evidenced by cases of electrocutions in nonhuman primates (NHPs). This study characterized the frequency, anatomic distribution, and Rafaela M. Barros, Isabel L. Macêdo, Davi E. R. Sousa, Liz A. Cerqueira, Yasmin N. G. Fonseca, Ana L. V. Sousa, Antonio D. Santos, Cristiano B. de Melo, Márcio B. Castro +8 morewiley +1 more sourceA LEAP Forward in Wildlife Conservation: A Standardized Framework to Determine Mortality Causes in Large GPS‐Tagged Birds
Ecology and Evolution, Volume 15, Issue 4, April 2025.A novel framework for determining the causes of mortality of large GPS‐tagged birds, the LIFE EUROKITE Assessment Protocol (LEAP), was developed. LEAP integrates GPS tracking data, site investigation, and necropsy to derive mortality causes and a corresponding certainty score. Two case studies demonstrated improvements in mortality assessments compared Connor T. Panter, Carina Nebel, Maximilian Raab, Verena Strauss, Clara Freytag, Manuel Wojta, Hannah Böing, Patrick Hacker, Rainhard Raab, Jendrik Windt, Annika Posautz, Anna Kuebber‐Heiss, Patrick Scherler, Martin U. Grüebler, Urs G. Kormann, Martin Kolbe, Alexandre Millon, Javier de la Puente, Javier Viñuela, Duncan Orr‐Ewing, Oliver Krone, Torsten Langgemach, Susanne Åkesson, Brady Mattsson, Petra Sumasgutner, Manuel Alcántara de la Fuente, Ernesto Alvarez, Juan Arizaga, Albert Bach Pagès, Ana Bermejo, Guido Ceccolini, Nayden Chakarov, Peter Derpmann‐Hagenström, Marek Dostál, Gerd Fabian, Wolfgang Fiedler, Manuel Galán, Clément Ganier, Andreas Gärtner, Liza Glesener, Alfonso Godino, Zuzana Guziová, László Haraszthy, Caka Karlsson, Katharina Klein, Ivan Literák, Nicolas Lorenzini, Manuela Löwold, Christopher Lüning, Boris Maderič, Karel Makoň, Kerstin Mammen, Ubbo Mammen, Torsten Marczak, Hynek Matušík, Aymeric Mionnet, Sara Morollón, Jakub Mráz, Winfried Nachtigall, Bernd Nicolai, Marta Olalde Fernández, Meinolf Ottensmann, María Jesús Palacios González, Jean‐Yves Paquet, Vladimír Pečeňák, Lubomír Peške, Thomas Pfeiffer, Robert Pudwill, Dušan Rak, Tim Maximilian Rapp, Alexander Resetaritz, Stef van Rijn, Romain Riols, Arturo Rodríguez, Luisa Scholze, Laura Schulte, Aurélie de Seynes, Jan Škrábal, Péter Spakovszky, Eike Steinborn, Ján Svetlík, Samuel Talhoet, Miklós Vaczi, Anne‐Gaelle Verdier, Zdenĕk Vermouzek, Diego Villanúa Inglada, Jörg Westphal, Rainer Raab +87 morewiley +1 more sourceInterleukin‐8/Matrix Metalloproteinase‐9 Axis Impairs Wound Healing in Type 2 Diabetes through Neutrophil Extracellular Traps‐Fibroblast Crosstalk
European Journal of Immunology, Volume 55, Issue 4, April 2025.Neutrophil extracellular traps (NETs) in type 2 diabetes induce a pro‐fibrotic but functionally impaired phenotype in cutaneous fibroblasts, associated with collagen breakdown by NET‐bound MMP‐9. IL‐8 released in NETs promotes its own expression in both neutrophils/fibroblasts and neutrophil MMP‐9 production, creating positive feedback loops that ...Dimitrios Tsilingiris, Anastasia‐Maria Natsi, Efstratios Gavriilidis, Christina Antoniadou, Ioanna Eleftheriadou, Ioanna A. Anastasiou, Anastasios Tentolouris, Evangelos Papadimitriou, Evgenios Eftalitsidis, Panagiotis Kolovos, Victoria Tsironidou, Alexandra Giatromanolaki, Maria Koffa, Nikolaos Tentolouris, Panagiotis Skendros, Konstantinos Ritis +15 morewiley +1 more sourceInduced Pseudomembrane Enrichment in Long Nerve Allograft Reconstruction
Muscle &Nerve, Volume 71, Issue 4, Page 662-669, April 2025.ABSTRACT Introduction/Aims
Long nerve defects are typically reconstructed with autograft or processed acellular nerve allograft (PNA). PNA is convenient and avoids donor morbidity but lacks the neurotrophic environment of autograft. Increased levels of neurotrophic factors have been identified in pseudomembranes induced around silicone implanted ...Omar A. Protzuk, Mariam A. Samuel, Kriston R. Seward, Christopher A. Keshishian, Geetanjali S. Bendale, Jonathan E. Isaacs +5 morewiley +1 more sourceThe effects of microprocessor prosthetic knee use in early rehabilitation: A pilot randomized controlled trial
PM&R, Volume 17, Issue 4, Page 371-383, April 2025.Abstract Background
Microprocessor‐controlled prosthetic knees (MPKs) improve safety, stability, and mobility for people with transfemoral amputation. Despite these benefits, MPKs are often not used for people in early rehabilitation. Objective
To assess the feasibility of a study that compares MPKs and nonmicroprocessor knees (NMPKs) for people with ...Sara J. Morgan, Janna L. Friedly, Ian K. Nelson, Rachael E. Rosen, Andrew T. Humbert, Brian J. Hafner +5 morewiley +1 more sourceA T2 Translational Science Modified Delphi Study: The Ethical Triage and Treatment of Entrapped and Mangled Extremities in Resource‐Scarce Environments
World Journal of Surgery, Volume 49, Issue 4, Page 1051-1060, April 2025.ABSTRACT Background
There is a lack of ethical triage and treatment guidelines for the entrapped and mangled extremity (E&ME) in resource‐scarce environments (RSE): mass casualty incidents, low‐ to middle‐income countries, complex humanitarian emergencies including conflict, and prolonged transport times (RSE).Eric S. Weinstein, Zachary Gilbert, James Gosney, Brielle Weinstein, Hannah B. Wild, Joseph Cuthbertson, Melissa Leming, Rachel Semmons, Dónal O'Mathúna, Carl Montan, Richard Gosselin, Frederick “Skip” Burkle +11 morewiley +1 more source