Results 71 to 80 of about 348,516 (280)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Amputation confers disabilities upon patients and is linked to substantial morbidity and death attributed to heart disease. While some studies have focused on traumatic amputees in veterans, few studies have focused on traumatic amputees ...
Hea Lim Choi, Jung Eun Yoo, Miso Kim, Bongsung Kim, Junhee Park, Won Hyuk Chang, Heesun Lee, Kyungdo Han, Dong Wook Shin   +8 more
doaj   +1 more source

Single‐dose enflicoxib versus a 7‐day course of firocoxib for postoperative pain control in dogs undergoing orthopaedic surgery: A multicentre, randomised, masked, non‐inferiority study

Veterinary Record, EarlyView.
Abstract Background Perioperative analgesia is essential in dogs undergoing orthopaedic surgery, and enflicoxib's long duration makes single‐dose administration attractive. Methods A prospective, multicentre, randomised, masked trial compared enflicoxib (8 mg/kg) given 24 hours before surgery with firocoxib (5 mg/kg) given daily for 7 days. Two hundred
Marta Salichs, José I. Redondo, Anabel Blasco‐Moreno, Llorenç Badiella, Josep Homedes   +4 more
wiley   +1 more source

Measuring patient disability in the peri‐operative period using the WHODAS 2.0 questionnaire: a systematic review

Anaesthesia, EarlyView.
Summary Introduction The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is recommended by peri‐operative core outcome sets as a measure of disability. Despite its growing use, the effect of different surgical procedures on disability measured by WHODAS 2.0 remains poorly understood and heterogeneous reporting across studies ...
Romijn M. Boerlage, Daniël van Dartel, Jacqueline E. M. Vernooij, Nick J. Koning, Linda M. Posthuma, Cor J. Kalkman, Carine J. M. Doggen, Benedikt Preckel   +7 more
wiley   +1 more source

The Intriguing History of Gloves and Their Application to Surgery

ANZ Journal of Surgery, EarlyView.
Gloves were first worn to protect against cold and injury. In surgery, their purpose now is to reduce surgical site infection and blood‐borne transmission of disease. Surprisingly, their adoption in surgery as a routine has been remarkably recent and had a bizarre origin.
Spencer W. Beasley
wiley   +1 more source

Amputations in Sepsis Patients: A Population‐Based Cohort Study of Rates and Risk Factors

ANZ Journal of Surgery, EarlyView.
This cohort study of 158 842 sepsis patients revealed that between 2015 and 2021 in NSW, 11 in every 1000 adult sepsis patients and two in every 1000 paediatric sepsis patients underwent amputation. Male adults under 85 years with diabetes or peripheral arterial disease were at a higher risk of amputation. ABSTRACT Background A rare and serious adverse
Khalia Ackermann, Nanda Aryal, Johanna Westbrook, Ling Li   +3 more
wiley   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

The benefits of multidisciplinary collaboration in the successful management of two complex feline cases

Australian Veterinary Journal, EarlyView.
Despite a frequent misconception that behavioural concerns are diagnoses of exclusion, medical conditions and behavioural disorders are frequently inter‐related. In human medicine, the ‘multidisciplinary team’ approach (MDTA) is considered the most efficacious way of managing patients with complex and chronic health conditions.
BE Bollaert, JM Ley, HE Zulch
wiley   +1 more source

From Theory to Practice: A Framework for Collaborative Anti‐Racist Research With Young Black Children

Children &Society, EarlyView.
ABSTRACT While researchers continue to make significant scholarly inroads toward the acknowledgment of Black children's agency and competencies, including their recognition of and resistance to systemic racism, practical guides to anti‐racist qualitative research with young Black children factor conspicuously less often into the contextual balance of ...
Kerry‐Ann Escayg, Amber M. Neal‐Stanley, Stephanie Fearon   +2 more
wiley   +1 more source

‘Do You Realise People Are Dying There?!’: Ukrainian Adolescents Reflecting on Death During Wartime

Children &Society, EarlyView.
ABSTRACT This article explores how Ukrainian refugee adolescents in Romania think and speak about death and loss amid war and displacement. While contemporary Western societies display an unprecedented visibility of death, they continue to exclude children from genuine conversations about mortality, maintaining a protective silence.
Adriana Teodorescu, Alina Bărbuță
wiley   +1 more source