Results 31 to 40 of about 304,494 (314)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

AMS-Qualifikations-Barometer (1): Ein Beitrag des AMS Österreich zur Erfassung des Qualifikationsbedarfes [PDF]

, 2004
Im Jänner 2002 wurden das Institut für Bildungsforschung der Wirtschaft (ibw) und die 3s Unternehmensberatung GmbH vom AMS Österreich beauftragt, mit der konkreten Umsetzung eines Instrumentes zur Darstellung von Qualifikationsund Berufsentwicklungen am ...
Archan, Sabine, Kargl, Maria, Markowitsch, Jörg   +2 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Are the ‘new’ AMS Varna dates older?

Българско е-Списание за Археология, 2013
The paper elaborates on the AMS dating results obtained for the Chalcolithic cemetery near Varna, located on the western Black Sea coast in northeastern Bulgaria.
Tanya Dzhanfezova
doaj  

Optimierung des Dienstleistungsangebotes des AMS für Wirtschaftsunternehmen: Eine Studie anhand des Beispiels AMS Kärnten [PDF]

, 2003
Dieses Projekt ist auftragsgemäß ein Beitrag zur Optimierung der Dienstleistungen des AMS Kärnten für seine betrieblichen Kunden. Im Mittelpunkt der Untersuchung steht eine Diskussion sowohl der betrieblichen Anforderungen an das unternehmensbezogene ...
Seiler, Eva-Christina, Saurug, Manfred
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Unterstützungsnotwendigkeiten des AMS zur Erleichterung des beruflichen Wiedereinstieges von Frauen: Eine Studie des AMS Vorarlberg [PDF]

, 2004
Die vorliegende Studie 'Unterstützungsnotwendigkeiten des AMS zur Erleichterung des beruflichen Wiedereinstieges nach längerer Beschäftigungspause', die im März 2004 im Auftrag des AMS Vorarlberg von dem Salzburger Institut Solution - Sozialforschung ...
Gschwandtner, Ulli, Buchinger, Birgit
core