Results 41 to 50 of about 736,868 (299)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Orientation on Amsterdam of people living outside town 1974

, 2007
Motivation for migration / visits to Amsterdam, frequency, transport, purpose / frequency and location of shopping, visits to cinema, theatre, cafe, etc.
Weesep, J. van, Korteweg, P.J., Vrije Universiteit Amsterdam * Amsterdam (primary investigator)
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhabitants of Amsterdam about crime and police, 1990

, 2007
General opinion about the police of Amsterdam and their surveillance / perceived chance to become a victim / feelings of insecurity in the whole city, in one's own district and in one's own house / actual victimization / opinion of victims and witnesses ...
Hoenson, L.F.H., Gemeentepolitie Amsterdam * Amsterdam, Bureau organisatie (primary investigator), Hoenson, L.F.H., Lofers Adema, R.H., Gemeentepolitie Amsterdam * Amsterdam, Bureau organisatie (primary investigator)   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Socio-economic indicators for Amsterdam neighbourhoods 1980-1986

, 2007
Socio-economic indicators of Amsterdam districts (stadsdelen) Data deriving from various municipal sources: employment-rates / income levels / educational levels from labour force count (AKT) 1981/ Demographic data: sex / marital status / family ...
Graeve, E., Gemeente Amsterdam * Amsterdam, Bureau voor Onderzoek en Statistiek, O+S (primary investigator)
core   +1 more source

Amsterdam, een maritieme stad? [PDF]

, 2009
Amsterdam maakte als maritiem centrum vanaf het einde van de zestiende eeuw een explosieve ontwikkeling door binnen een zich voortdurend uitbreidend scheepvaartnetwerk.
Gawronski, J., Jerzy Gawronski, Gawronski, Jerzy   +2 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Sports activities of members of ethnic minority groups in Amsterdam 1986

, 2007
Participation in sports activities by members of ethnic minority groups in Amsterdam. Sports activities ( competitive and recreation sports ) in clubs / in sports hall of the local authorities / sports activities at school / frequency of sports ...
Hoolt, J., Gemeente Amsterdam * Amsterdam, Bestuursinformatie, afd. onderzoek en statistiek (primary investigator)
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source