Results 301 to 310 of about 516,976 (376)

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Brain cholinergic terminal density utilizing [¹⁸F]-fluoroethoxybenzovesamicol PET in adults with Down's syndrome: Relationship to amyloid PET and cognitive performance. [PDF]

Alzheimers Dement
Russell JK, Conley AC, Boyd BD, Begnoche JP, Schlossberg R, Stranick A, Rosenberg AJ, Acosta LMY, Martin D, Neal Y, Rafii MS, Dumas J, Newhouse PA.   +12 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Identifying squamous cell carcinoma and cytokeratin-derived amyloid with pan-cytokeratin AE1/AE3 during Mohs micrographic surgery

JAAD Case Reports, 2020
Kirk Sidey, MD, MBA, Ajdin Kobic, MD, Nahid Y. Vidal, MD   +2 more
doaj  

Emotional distress following amyloid PET result disclosure: Heightened among those with cognitive symptoms. [PDF]

Alzheimers Dement
Kim JE, Ren D, Cohen AD, Lopez OL, Lingler JH.   +4 more
europepmc   +1 more source

Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

BioEssays, EarlyView.
Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler, Gian Gaetano Tartaglia, Annalisa Pastore   +2 more
wiley   +1 more source

Apolipoprotein E in Alzheimer's disease: molecular insights and therapeutic opportunities. [PDF]

Mol Neurodegener
Belaidi AA, Bush AI, Ayton S.
europepmc   +1 more source

N-Acetylcysteine for Hereditary Cystatin C Amyloid Angiopathy: A Nonrandomized Clinical Trial.

JAMA Neurol
Snorradottir AO, Gutierrez-Uzquiza A, Bragado P, March ME, Kao C, Arkink EB, Jonsdottir S, Sigurdardottir A, Isaksson HJ, Mariasdóttir HL, Bjorgvinsdottir OY, Kowal NM, Heimisdottir HL, Sverrisdottir A, Palsdottir A, Bjornsson HT, Hakonarson H.   +16 more
europepmc   +1 more source

Amyloid β-related Angiitis Presenting with Subarachnoid Hemorrhage Diagnosed by Brain Biopsy: A Case Report. [PDF]

NMC Case Rep J
Ishida M, Shimoya N, Shibata H, Ohno T, Iwata T, Taishaku A, Yamada K, Inaguma S, Aihara N.   +8 more
europepmc   +1 more source

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy. [PDF]

Beilstein J Nanotechnol
Randhawa S, Saini TC, Bathla M, Bhardwaj R, Dhiman R, Acharya A.   +5 more
europepmc   +1 more source