Results 351 to 360 of about 94,035 (378)

X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid .beta.-protein precursor

Biochemistry, 1990
Alzheimer's amyloid beta-protein precursor contains a Kunitz protease inhibitor domain (APPI) potentially involved in proteolytic events leading to cerebral amyloid deposition. To facilitate the identification of the physiological target of the inhibitor, the crystal structure of APPI has been determined and refined to 1.5-A resolution.
Laura Kennedy, Charles Eigenbrot, Michael Randal, Thomas R. Hynes, Anthony A. Kossiakoff   +4 more
openaire   +3 more sources

A novel mutation in the ?-protein coding region of the amyloid ?-protein precursor (APP) gene

Human Genetics, 1992
A novel mutation, a C to T transition at base pair 2124 in exon 17 of the amyloid beta-protein precursor (APP) gene, has been identified by direct sequencing of amplified DNA from two Alzheimer's disease (AD) patients. A simple oligonucleotide-hybridization procedure was developed to allow population studies of this DNA variation.
Arne Brun, Magnus Abrahamson, Lars Gustafson, Milagros Balbín, Anders Grubb, Karin Nilsson   +5 more
openaire   +3 more sources

The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein

Biological Psychiatry, 1996
Lars Lannfelt, J. Jensen, X. Song, John Hardy, Gerard D. Schellenberg, Rudolph E. Tanzi, Christopher B. Eckman, Steve Younkin, C-M Prada, Nobuhiro Suzuki, D. Scheuner, Dennis J. Selkoe   +11 more
openaire   +2 more sources

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

The EMBO Journal, 1987
Clones for the amyloid beta protein precursor gene were isolated from a cDNA library prepared from the frontal cortex of a patient who had died with a histologically confirmed diagnosis of Alzheimer's disease; they were used to investigate the tissue and cellular distribution of amyloid beta protein precursor mRNA in brain tissues from control patients
openaire   +3 more sources

THE AMYLOID BETA PROTEIN PRECURSOR GENE CONTAINS A COMPLEX TRANSCRIPTIONAL UNIT

Alzheimer Disease & Associated Disorders, 1988
J. R. Gilbert, J. W. Teener, D. C. Gajdusek, A. D. Roses, D. Goldgaber   +4 more
openaire   +2 more sources

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Nature Reviews Drug Discovery, 2022
Eric Karran, Bart De Strooper, Haohong Duan   +2 more
exaly  

Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids

Chemical Reviews, 2021
Dieter Willbold, Birgit Strodel, Gunnar F Schröder   +2 more
exaly  

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Alfonso De Simone, Andrew J Doig, Antoine Loquet   +2 more
exaly  

2016 US lymphoid malignancy statistics by World Health Organization subtypes

Ca-A Cancer Journal for Clinicians, 2016
Lauren R Teras, Carol E Desantis, James R Cerhan   +2 more
exaly  

Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies

Ca-A Cancer Journal for Clinicians, 2016
Peter A S Johnstone, Anna R Giuliano
exaly