Results 1 to 10 of about 816 (114)
Mass Spectrometry Reviews, Volume 42, Issue 5, Page 1984-2206, September/October 2023., 2023 Abstract This review is the tenth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2020.
David J. Harvey
wiley +1 more source
EAACI Molecular Allergology User's Guide 2.0
Pediatric Allergy and Immunology, Volume 34, Issue S28, March 2023., 2023 Abstract Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of ...
Stephanie Dramburg +100 more
wiley +1 more source
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
The EMBO Journal, Volume 41, Issue 8, 19 April 2022., 2022 C‐terminal TDP‐43 hyperphosphorylation may be a protective cellular response to counteract TDP‐43 aggregation, rather than a driver of neuropathology as previously assumed. Abstract Post‐translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neurodegenerative ...
Lara A Gruijs da Silva +11 more
wiley +1 more source
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Presently, with the introduction of nanotechnology, the evolutions and applications of biosensors and/or nanobiosensors are becoming prevalent in various scientific domains such as environmental and agricultural sciences as well as biomedical, clinical, and healthcare sciences.
Kingsley Eghonghon Ukhurebor +9 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Crocus species are mainly distributed in North Africa, Southern and Central Europe, and Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus L. (saffron) is the only species that is cultivated for edible purpose. The use of saffron is very ancient; besides the use as a spice, saffron has long been known also for its ...
Monica Butnariu +19 more
wiley +1 more source
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation
The EMBO Journal, Volume 40, Issue 21, 02 November 2021., 2021 While amyloidogenic proteins are often stabilized by their supercharged segments, the specific interaction with and shielding of these charges by MOAG/SERF2 drives aggregation of amyloidogenic proteins in vitro and in vivo. Abstract While aggregation‐prone proteins are known to accelerate aging and cause age‐related diseases, the cellular mechanisms ...
Anita Pras +19 more
wiley +1 more source
Autophagy in major human diseases
The EMBO Journal, Volume 40, Issue 19, 01 October 2021., 2021 This review provides an exhaustive overview of the contribution of autophagy to multiple pathological phenotypes in vivo, and discusses the therapeutic potential of autophagy modulation in disease prevention and treatment. Abstract Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis.
Daniel J Klionsky +58 more
wiley +1 more source
The EMBO Journal, Volume 40, Issue 6, 15 March 2021., 2021 Binding of K63‐linked ubiquitin chains via a tightly‐linked accessory domains allows two homologous human and yeast E2 enzymes to add further K48‐linked moieties and build branched conjugates. Abstract The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regulation of numerous cellular processes.
Lukas Pluska +11 more
wiley +1 more source
Evolutionary Applications, Volume 14, Issue 2, Page 476-497, February 2021., 2021 Abstract Various strains of the mycoparasitic fungal species Clonostachys rosea are used commercially as biological control agents for the control of fungal plant diseases in agricultural crop production. Further improvements of the use and efficacy of C. rosea in biocontrol require a mechanistic understanding of the factors that determines the outcome
Martin Broberg +8 more
wiley +1 more source
Succinct Amyloid and Non-Amyloid Patterns in Hexapeptides [PDF]
arXiv, 2022 Hexapeptides are widely applied as a model system for studying amyloid-forming properties of polypeptides, including proteins. Recently, large experimental databases have become publicly available with amyloidogenic labels. Using these datasets for training and testing purposes, one may build artificial intelligence (AI)-based classifiers for ...
arxiv