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Acquired and Genetic Amyloid Neuropathies
Neurologic ClinicsAmyloidosis is a potentially treatable cause of polyneuropathy with various distinct etiologies, including amyloid light chain (AL), transthyretin variant (ATTRv), wild-type transthyretin amyloidosis (wrATTR), gelsolin, and apolipoprotein A1 (ApoA-I). Among these, AL and transthyretin amyloidosis are the most common, while AGel and ApoA-I amyloidosis ...
Chafic Karam +2 more
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Current and future treatment of amyloid neuropathies
Expert Review of Neurotherapeutics, 2014Amyloid neuropathies of acquired or genetic origin are disabling and life-threatening, until recently there were few treatment options available. Poor prognosis is related to progressive neuropathy and associated, although often underdiagnosed, cardiac involvement in specific transthyretin (TTR) gene mutations.
David Adams +2 more
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Amyloidosis and its management: Amyloid neuropathies
Current Problems in Cancer, 2016Kathleen Thornton, Pearson, Scott, Vota
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Archives of Neurology, 2001
The first pathological descriptions of amyloid have been attributed to von Rokitansky, 1 2 who in 1842 described the waxy or lardaceous changes in the liver and spleen as infiltration by a grey, albuminous, gelatinous substance. 3 Although scattered clinical descriptions of liver infiltration had been recorded as early as 1722, von Rokitansky's ...
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The first pathological descriptions of amyloid have been attributed to von Rokitansky, 1 2 who in 1842 described the waxy or lardaceous changes in the liver and spleen as infiltration by a grey, albuminous, gelatinous substance. 3 Although scattered clinical descriptions of liver infiltration had been recorded as early as 1722, von Rokitansky's ...
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NEUROPATHY, M COMPONENTS, AND AMYLOID
The Lancet, 1975Of eighty-seven patients with nonhereditary systemic amyloidosis, ten had evidence of peripheral neuropathy. There was median-nerve neuropathy due to infiltration of the flexor retinaculum with amyloid in six patients. Two patients had diffuse sensorimotor neuropathy and two patients had sensory loss without evidence of motor impairment--three of these
M D, Benson +3 more
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Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)
Amyloid neuropathy is a rare condition characterized by the pathological deposition of amyloid fibrils within the peripheral and autonomic nervous systems, leading to progressive sensorimotor and autonomic dysfunction. More than 15 types of systemic amyloidosis have been identified, each associated with a specific precursor protein involved in the ...
I. M. Efimov +7 more
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Amyloid neuropathy is a rare condition characterized by the pathological deposition of amyloid fibrils within the peripheral and autonomic nervous systems, leading to progressive sensorimotor and autonomic dysfunction. More than 15 types of systemic amyloidosis have been identified, each associated with a specific precursor protein involved in the ...
I. M. Efimov +7 more
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MOLECULAR GENETICS OF AMYLOID NEUROPATHY IN EUROPE
The Lancet, 1989The Portuguese type of familial amyloid polyneuropathy (FAP type I), a disabling autosomal dominant disorder with onset in early adult life, is caused by a point mutation in the transthyretin (TTR; previously known as prealbumin) gene. DNA analysis in thirteen European families (one British, two French, one Italian, one Greek, and eight Cypriot) showed
RichardL. Roudebush, MerrillD. Benson
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Amyloid Neuropathy: Relationship between Amyloid Fibrils and Macrophages
Ultrastructural Pathology, 1984A case of amyloid neuropathy associated with a multiple myeloma IgG light chain is reported. Under light microscopy the peripheral nerve exhibited several amyloid deposits. Electron microscopy revealed numerous amyloid deposits; at their periphery, macrophagic histiocytes were observed, containing a few tufts of parallel fibrils in their cytoplasm.
A, Vital, C, Vital
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